Weight management program alongside fertility-sparing treatment for endometrial cancer in overweight patients
Tests a weight management program in overweight women with endometrial cancer keeping fertility.
Plain-language title generated from the registry record
Registry title: Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- Peking University People's HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking University People's Hospital
- Trial code
- NCT07879365
- Record updated
- 16 October 2026
- Original description
This study will randomly assign overweight or obese patients with endometrial cancer undergoing fertility-sparing treatment to two groups. The intervention group will receive a comprehensive weight management program based on the DEAR principles of Diet, Exercise, Accompany, and Refresh, including intermittent fasting and structured aerobic exercise. The control group will receive balanced dietary guidance and self-directed exercise. Both groups will receive family and healthcare support, sleep monitoring, and stress-management support. By evaluating pathological complete response, body mass index, glucose and lipid metabolism, and serum AMP-activated protein kinase (AMPK) levels, this study aims to determine the effectiveness and safety of DEAR-based weight management in patients with endometrial cancer undergoing fertility-sparing treatment.Read full original descriptionShow less
A Clinical Study of Weight Management-Induced AMPK Activation as an Adjunctive Treatment for Endometrial Cancer
This study will randomly assign overweight or obese patients with endometrial cancer undergoing fertility-sparing treatment to two groups. The intervention group will receive a comprehensive weight management program based on the DEAR principles of Diet, Exercise, Accompany, and Refresh, including intermittent fasting and structured aerobic exercise. The control group will receive balanced dietary guidance and self-directed exercise. Both groups will receive family and healthcare support, sleep monitoring, and stress-management support. By evaluating pathological complete response, body mass index, glucose and lipid metabolism, and serum AMP-activated protein kinase (AMPK) levels, this study aims to determine the effectiveness and safety of DEAR-based weight management in patients with endometrial cancer undergoing fertility-sparing treatment.
Inclusion: Aged 18 years or older; Diagnosed with endometrial cancer; Have undergone immunohistochemical staining of pathological tissue samples and sequencing analysis; Receiving fertility-sparing treatment; Body mass index ≥ 24 kg/m²; Provided written informed consent to participate in the study.
Exclusion: Patients with severe medical or surgical comorbidities, including urinary tract stones, a history of renal failure or severe renal impairment, familial dyslipidemia, severe liver disease, chronic metabolic acidosis, a history of pancreatitis, severe diabetes mellitus, active gallbladder disease, disorders of fat digestion, severe cardiovascular disease, cerebrovascular disease, or other serious comorbidities; Patients with communication difficulties; Pregnant patients.