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Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

Key facts

Who runs it
Balikesir Ataturk City Hospital
Where
Türkiye1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
230 people, planned
Started
26 Jun 2026
Expected to end
Aug 2028
Type of study
Observational
Record updated
4 November 2026

Who can take part

Age
18 years and older
Sex
Women and men

The registry criteria, word for word

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Who can take part

  • Adults aged 18 years or older
  • Scheduled for elective unilateral primary total knee arthroplasty due to primary knee osteoarthritis
  • Sufficient cognitive and communication abilities to understand and complete the study questionnaires
  • Provision of written informed consent for study participation

Who cannot take part

  • Arthroplasty indicated for inflammatory arthritis, tumor, infection, or post-traumatic conditions
  • Severe cognitive impairment, advanced dementia, or communication difficulties preventing valid completion of the study questionnaires
  • Patients scheduled for revision total knee arthroplasty
  • Patients scheduled for simultaneous bilateral total knee arthroplasty
  • Significant logistical or legal circumstances preventing completion of the planned follow-up assessments

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.

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Approximately 230 adult patients undergoing elective unilateral primary TKA will be enrolled at a single hospital in Türkiye. Preoperative multimorbidity burden will be assessed using the Functional Comorbidity Index (FCI), which measures the presence of medical conditions that may affect physical function.

Patients will be evaluated before surgery and at 6 and 12 months after surgery. Functional outcomes and pain will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford Knee Score (OKS). Anxiety and depressive symptoms will be evaluated using the Hospital Anxiety and Depression Scale (HADS).

The primary objective is to determine whether higher preoperative multimorbidity burden is associated with poorer physical function at 12 months after TKA. The study will also examine changes in functional recovery over time and other clinical outcomes.

All surgical procedures, postoperative care, and rehabilitation will follow routine clinical practice. No additional treatment or experimental intervention will be assigned as part of this study.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Effect of Preoperative Multimorbidity Burden on the Trajectory of Functional Recovery After Primary Total Knee Arthroplasty: A Single-Center Prospective Observational Cohort Study
Record updated
4 November 2026