Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
Key facts
- Who runs it
- Balikesir Ataturk City Hospital
- Where
- Balıkesir, TürkiyeSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 230 people, planned
- Started
- 26 Jun 2026
- Expected to end
- Aug 2028
- Type of study
- Observational
- Record updated
- 4 November 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
The registry criteria, word for word
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Who can take part
- Adults aged 18 years or older
- Scheduled for elective unilateral primary total knee arthroplasty due to primary knee osteoarthritis
- Sufficient cognitive and communication abilities to understand and complete the study questionnaires
- Provision of written informed consent for study participation
Who cannot take part
- Arthroplasty indicated for inflammatory arthritis, tumor, infection, or post-traumatic conditions
- Severe cognitive impairment, advanced dementia, or communication difficulties preventing valid completion of the study questionnaires
- Patients scheduled for revision total knee arthroplasty
- Patients scheduled for simultaneous bilateral total knee arthroplasty
- Significant logistical or legal circumstances preventing completion of the planned follow-up assessments
Where in Türkiye
- Güneş SarikayaBalıkesir, TürkiyeContact: Güneş SARIKAYATaking people
About the trial
What the trial wants to find out
This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.
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Approximately 230 adult patients undergoing elective unilateral primary TKA will be enrolled at a single hospital in Türkiye. Preoperative multimorbidity burden will be assessed using the Functional Comorbidity Index (FCI), which measures the presence of medical conditions that may affect physical function.
Patients will be evaluated before surgery and at 6 and 12 months after surgery. Functional outcomes and pain will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford Knee Score (OKS). Anxiety and depressive symptoms will be evaluated using the Hospital Anxiety and Depression Scale (HADS).
The primary objective is to determine whether higher preoperative multimorbidity burden is associated with poorer physical function at 12 months after TKA. The study will also examine changes in functional recovery over time and other clinical outcomes.
All surgical procedures, postoperative care, and rehabilitation will follow routine clinical practice. No additional treatment or experimental intervention will be assigned as part of this study.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effect of Preoperative Multimorbidity Burden on the Trajectory of Functional Recovery After Primary Total Knee Arthroplasty: A Single-Center Prospective Observational Cohort Study
- Record updated
- 4 November 2026