Studying twisted or kinked neck arteries and their effects on the brain
Follows adults with twisted internal carotid arteries to see effects on brain function.
Plain-language title generated from the registry record
Registry title: Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
Key facts
- Where
- Krasnodar, RussiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07882875, who can take part
Where in Russia
- Research Institute-Regional Clinical Hospital No. 1 Named After Prof. S.V. OchapovskyKrasnodar, RussiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kuban State Medical University
- Trial code
- NCT07882875
- Record updated
- 20 October 2026
- Original description
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and adverse cerebrovascular outcomes. The study combines retrospective clinical data with prospective follow-up of patients with verified internal carotid artery dolichoarteriopathy. Anatomical, hemodynamic, neuroimaging, clinical, cognitive, and biomarker characteristics will be evaluated to develop and validate a multimodal approach to risk stratification. Outcomes will also be compared between patients managed surgically and conservatively according to routine clinical indications. Treatment decisions are made independently by the treating physicians and are not assigned by the study protocol.Read full original descriptionShow less
Personalized Treatment Strategy for Internal Carotid Artery Dolichoarteriopathy Based on Objective Assessment of Cerebral Dysfunction and Outcome Prediction
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and adverse cerebrovascular outcomes. The study combines retrospective clinical data with prospective follow-up of patients with verified internal carotid artery dolichoarteriopathy. Anatomical, hemodynamic, neuroimaging, clinical, cognitive, and biomarker characteristics will be evaluated to develop and validate a multimodal approach to risk stratification. Outcomes will also be compared between patients managed surgically and conservatively according to routine clinical indications. Treatment decisions are made independently by the treating physicians and are not assigned by the study protocol.
Inclusion: Age 18 to 75 years, inclusive; Verified pathological deformation of the internal carotid artery, including tortuosity, kinking, and/or coiling, confirmed by duplex ultrasound and/or angiographic imaging; Ability to undergo baseline clinical and neurological assessment and longitudinal follow-up; Written informed consent for participation and processing of personal data. Separate optional consent may be obtained for storage of residual biospecimens and genetic testing, where applicable.
Exclusion: Acute ischemic or hemorrhagic stroke within 6 months before planned enrollment if the participant's condition prevents valid baseline assessment or study procedures; Myocardial infarction within the previous 3 months; Unstable angina, NYHA class III-IV heart failure, or another decompensated cardiovascular condition that prevents safe participation; Severe cognitive impairment or dementia preventing valid informed consent or neuropsychological assessment, unless participation is legally permitted through an authorized representative; Active malignancy or systemic treatment expected to substantially affect the investigated biomarkers or prognosis; Decompensated respiratory, renal, or hepatic disease that may substantially affect safety or interpretation of study results; Psychiatric disorder or other condition preventing adequate communication or adherence to the study protocol; Complete occlusion of the study internal carotid artery or brachiocephalic trunk that prevents valid assessment of the pathophysiological role of arterial tortuosity; Hemodynamically significant atherosclerotic stenosis of the internal carotid artery greater than 50% on the side relevant to the analysis when it represents the dominant alternative cause of impaired blood flow.