How one exercise session affects brain function in people with neurological conditions
Tests how a single bike exercise session changes brain function in neurological disease.
Plain-language title generated from the registry record
Registry title: EXercise-induced PhysioLogical Adaptations In Neurological Disorders
Key facts
- Where
- Boston, United StatesSee the site
Where in United States
- Brigham and Women's HospitalBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Brigham and Women's Hospital
- Trial code
- NCT07883720
- Record updated
- 20 October 2026
- Original description
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are:Read full original descriptionShow less
Exercise Testing for Neurological Conditions
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are:
* How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases?
Participants will take part in a single, one-day study visit and will be asked to:
* Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test
Inclusion: 18 years or older; Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor [for participants with neurological diseases]; No diagnosis of neurological disease [for healthy control participants].
Exclusion: Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy); Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures); Current use of medications for cardiac rhythm or rate control; Non-english speaking individuals.