Effect of Resistance Exercises on Serum IGF-1 Levels in Knee Osteoarthritis
Key facts
- Where
- Istanbul, TürkiyeSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
Source: NCT07890155, who can take part
Where in Türkiye
- Şişli Hamidiye Etfal Training and Research HospitalIstanbul, TürkiyeContact: Bora Şahin, MD, PMR Resident PhysicianTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Sisli Hamidiye Etfal Training and Research Hospital
- Trial code
- NCT07890155
- Record updated
- 22 October 2026
- Original description
The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis. Specifically, it aims to investigate the relationship between changes in serum IGF-1 levels and clinical improvement after exercise therapy, and to evaluate the impact of the presence of osteoarthritis metabolic phenotype on this relationship.Read full original descriptionShow less
Changes in Serum IGF-1 Levels With Resistance Exercises in Patients With Knee Osteoarthritis and Their Association With Clinical and Radiological Parameters
The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis. Specifically, it aims to investigate the relationship between changes in serum IGF-1 levels and clinical improvement after exercise therapy, and to evaluate the impact of the presence of osteoarthritis metabolic phenotype on this relationship.
Participants will be asked to complete a structured resistance exercise program for 8 weeks.
Researchers will compare the pre-exercise and post-exercise serum IGF-1 levels, clinical scores (WOMAC, VAS) and radiological findings (MOAKS Osteophyte Score) to determine the effectiveness of the intervention.
Inclusion: Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) clinical and radiographic criteria; Radiological severity of Kellgren-Lawrence (KL) grade 2 or 3 on standing anteroposterior knee radiographs; Having a knee magnetic resonance imaging (MRI) scan obtained within the past 1 year; Age between 40 and 75 years; Volunteering to participate in the study and signing the informed consent form.
Exclusion: Receiving intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) in the affected knee within the last 6 months; History of previous major knee surgery, knee arthroplasty, or lower extremity trauma affecting biomechanics; Diagnosis of rheumatoid arthritis, or other inflammatory joint diseases; Presence of severe cardiovascular, neurological, or musculoskeletal disorders that would contraindicate or prevent participation in a structured resistance exercise program; History of malignancy or presence of active malignancy; Presence of active infection; Cognitive impairment or inability to understand and follow the exercise instructions and questionnaires.