Brain stimulation to help arm recovery in the early weeks after ischemic stroke
Tests a brain stimulation device for arm movement after ischemic stroke.
Plain-language title generated from the registry record
Registry title: Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07896629, who can take part
Where in China
- Xuanwu Hospital, Capital Medical UniversityBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT07896629
- Record updated
- 6 November 2026
- Original description
This study aims to test whether transcranial temporal interference stimulation (tTIs) can improve upper limb motor function in patients in the early subacute stage after acute ischemic stroke. Participants will be randomly assigned to receive either active tTIs treatment or sham stimulation. All subjects will receive routine rehabilitation. The treatment will be given once daily for 20 consecutive days. Researchers will assess upper limb motor function before treatment, during the intervention and after the treatment course to compare the effect between the two groups. Safety will also be monitored throughout the study.Read full original descriptionShow less
Effects of Transcranial Temporal Interference Stimulation on Upper-Limb Motor Recovery in Early Subacute Ischemic Stroke: A Randomized, Double-Blind, Sham-Controlled Pilot Trial
This study aims to test whether transcranial temporal interference stimulation (tTIs) can improve upper limb motor function in patients in the early subacute stage after acute ischemic stroke. Participants will be randomly assigned to receive either active tTIs treatment or sham stimulation. All subjects will receive routine rehabilitation. The treatment will be given once daily for 20 consecutive days. Researchers will assess upper limb motor function before treatment, during the intervention and after the treatment course to compare the effect between the two groups. Safety will also be monitored throughout the study.
Inclusion: First-ever ischemic stroke occurring 7 days to 3 months before enrollment; Unilateral anterior-circulation ischemic stroke confirmed by CT or MRI; Receipt of reperfusion therapy; Age 18-80 years; Upper-limb motor impairment, defined as an FMA-UE score of ≤42; Right-handedness, as determined by the Edinburgh Handedness Inventory; Ability to understand and communicate adequately, willingness to participate, and provision of written informed consent.
Exclusion: Previous history of stroke, either ischemic or hemorrhagic; Severe cognitive impairment or psychiatric symptoms; Bilateral brain lesions or other neurological disorders, including Parkinson's disease, epilepsy, or brain tumors; Severe cardiac, pulmonary, hepatic, renal, or other major organ dysfunction; Skull defects; Increased intracranial pressure; Contraindications to MRI, including incompatible intracranial or external metal objects or implanted devices such as pacemakers or infusion pumps; Current participation in another clinical trial; Inability to complete the treatment or follow-up procedures, poor adherence, or adverse reactions to electrical stimulation that prevent continued participation; Pregnancy or breastfeeding.