Brown fat heat responses in women with polycystic ovary syndrome, with an inositol supplement
Measures brown fat heat in women with polycystic ovary syndrome, testing inositol supplement.
Plain-language title generated from the registry record
Registry title: Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
Key facts
- Where
- Istanbul, TürkiyeSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for premenopausal women aged 18-40 years: women with polycystic ovary syndrome (PCOS) at a normal weight, women with PCOS who are overweight or have obesity, and healthy women without PCOS.
- Age
- 18-40 years
- Sex
- Women only (premenopausal)
- Disease stage
- PCOS diagnosed by a gynecologist using the Rotterdam criteria; healthy women need regular menstrual cycles and normal ovaries.
- Earlier treatment
- No treatment for PCOS in the previous 6 months, including medicines or acupuncture. No obesity surgery or anti-obesity medicine in the past.
- Biomarker or test result
- BMI 18.5-24.9 kg/m² for the normal-weight PCOS group and the healthy group. BMI ≥25 kg/m² for the overweight/obesity PCOS group.
Main reasons for not taking part
- Pregnancy or breastfeeding
- Regular smoking or alcohol use
- Regular exercise in the previous 6 months, or being a professional athlete
- Thyroid disease, congenital adrenal hyperplasia, androgen-secreting tumors or Cushing syndrome
- Regular medicine use, such as oral contraceptives or hormonal medicines, within the previous 3 months or now
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT07896642, who can take part
Where in Türkiye
- Bezmialem Vakif University Faculty of Medicine HospitalIstanbul, TürkiyeContact: Seda Ateş, MDTaking people
- Istanbul Health and Technology UniversityIstanbul, TürkiyeContact: Hayrettin Mutlu, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Istanbul Health and Technology University
- Trial code
- NCT07896642
- Record updated
- 12 November 2026
- Original description
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared. Brown adipose tissue-related heat responses will be evaluated using non-invasive infrared thermography of the supraclavicular region, together with serum UCP-1 levels and metabolic measurements. Participants in the overweight/obesity PCOS group will receive an inositol supplement for 12 weeks, and measurements will be repeated after supplementation. The study will also examine possible relationships between surface temperature responses, dietary intake, physical activity, body measurements, and metabolic and hormonal markers.Read full original descriptionShow less
Investigation of Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared. Brown adipose tissue-related heat responses will be evaluated using non-invasive infrared thermography of the supraclavicular region, together with serum UCP-1 levels and metabolic measurements. Participants in the overweight/obesity PCOS group will receive an inositol supplement for 12 weeks, and measurements will be repeated after supplementation. The study will also examine possible relationships between surface temperature responses, dietary intake, physical activity, body measurements, and metabolic and hormonal markers.
Inclusion: Female participants aged 18-40 years; Premenopausal status; Ability and willingness to provide written informed consent; For the Overweight/Obesity PCOS - Inositol and Normal-BMI PCOS Reference Group arms:; Diagnosis of polycystic ovary syndrome (PCOS) established by an obstetrician and gynecologist according to the Rotterdam criteria; For the Normal-BMI PCOS Reference Group arm:; BMI 18.5-24.9 kg/m²; For the Overweight/Obesity PCOS - Inositol arm:; BMI ≥25 kg/m²; For the Healthy Control Group arm:; BMI 18.5-24.9 kg/m²; Regular menstrual cycles; Normal ovarian morphology; No diagnosis of PCOS.
Exclusion: Being highly physically active, defined as regular exercise during the previous 6 months or being a professional athlete; Any intervention for PCOS treatment within the previous 6 months, including pharmacological treatment or alternative approaches such as acupuncture; Regular medication use within the previous 3 months or currently, particularly oral contraceptives, hormonal medications, or medications affecting metabolism; Presence of endocrine disorders that may affect the diagnosis of PCOS, including thyroid disease, congenital adrenal hyperplasia, androgen-secreting tumors, or Cushing syndrome; History of ovarian surgery; Presence of any of the following conditions:; Secondary hypertension; Cardiovascular, cerebrovascular, renal, hepatic, thyroid, or pulmonary disease; Any type of cancer; Acute infection; Autoimmune disease; Severe psychological or neurological disease; History of obesity-specific treatment, including bariatric surgery or anti-obesity medication; Age ≤17 years or ≥41 years; Male sex; Menopausal status; BMI <18.5 kg/m²; Pregnancy or breastfeeding; Regular smoking or alcohol consumption; Following a special diet that may affect metabolic rate, including vegetarian, vegan, diabetic, or low-calorie diets; Regular use of dietary supplements such as probiotics or prebiotics.