Cooling the brain through an artery after clot removal in basilar artery stroke
Tests cold saline through an artery after clot removal in adults with basilar artery stroke.
Plain-language title generated from the registry record
Registry title: Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
Key facts
- Where
- Guangzhou and Hefei, ChinaSee the 2 sites
Where in China
- Guangdong Second Provincial General HospitalGuangzhou, ChinaNo longer taking part
- The First Affiliated Hospital of University of Science and Technology of ChinaHefei, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guangdong Second Provincial General Hospital
- Trial code
- NCT07896655
- Record updated
- 6 November 2026
- Original description
This study will examine whether cooling part of the brain through a catheter after endovascular treatment improves recovery in adults with acute basilar artery occlusion, a type of severe stroke. After blood flow has been successfully restored, 818 participants will be randomly assigned to receive either cold saline or room-temperature saline through an artery. The main outcome is the level of disability 90 days later, measured using the modified Rankin Scale. The study will also assess safety, including bleeding in the brain and other complications.Read full original descriptionShow less
Selective Intra-Arterial Hypothermia Combined With Endovascular Treatment for Acute Basilar Artery Occlusion (CHILL- BAO): A Multicenter, Prospective, Open-Label, Blinded-Endpoint, Randomized Controlled Trial
This study will examine whether cooling part of the brain through a catheter after endovascular treatment improves recovery in adults with acute basilar artery occlusion, a type of severe stroke. After blood flow has been successfully restored, 818 participants will be randomly assigned to receive either cold saline or room-temperature saline through an artery. The main outcome is the level of disability 90 days later, measured using the modified Rankin Scale. The study will also assess safety, including bleeding in the brain and other complications.
Inclusion: Age ≥ 18 years; Sudden onset of focal or global neurological deficit symptoms; Emergency imaging (CTA, MRA, or DSA) prior to randomization confirms occlusion of the basilar artery or vertebral artery. In the case of vertebral artery occlusion, bidirectional blood flow to the basilar artery must be completely obstructed, accompanied by corresponding neurological deficit symptoms; EVT is initiated within 24 hours of symptom onset; The National Institutes of Health Stroke Scale (NIHSS) score is ≥10 before the start of the procedure; Pc-ASPECTS ≥3; Pre-stroke mRS score of 0-1; Randomization Trigger Conditions:; (1)Successful recanalization of the basilar artery after endovascular treatment; (2)Definition of successful recanalization: eTICI grade reaching 2b, 2c,or 3; 9.The patient or their legal guardian is able to understand the purpose of the trial, voluntarily participate and sign a written informed consent form, and is capable of undergoing clinical follow-up.
Exclusion: Hypothermia-specific contraindications： (1)Hypothermia: Baseline core body temperature (rectal) <36.0°C; (2)History of cryoglobulinemia, sickle cell anemia, or Raynaud's disease; Life expectancy <90 days (due to other fatal diseases); 4.Currently participating in other clinical trials; in the research or follow-up phase; High-risk cardiac factors:; (1)Sick sinus syndrome (SSS); (2)Second-degree type II or third-degree atrioventricular block (without pacemaker implantation); (3)Baseline heart rate <50 bpm or QTc >500 ms; (4)History of severe heart failure (LVEF <30%); 3.Severe clinical status:; Refractory shock: admission systolic blood pressure <90 mmHg requiring combined or high-dose vasopressors for maintenance; Pregnant or lactating women.