Looking back at menin inhibitor treatment in children with relapsed or refractory acute leukemia
Reviews past records of children with acute leukemia treated with menin inhibitors.
Plain-language title generated from the registry record
Registry title: Menin Inhibitors in Pediatric Relapsed or Refractory Acute Leukemia
Key facts
- Where
- Strasbourg, FranceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
This French study looks back at children with acute leukemia that came back or did not respond to treatment, who were given a menin inhibitor. The trial is looking for children with a KMT2A or NUP98 rearrangement or an NPM1 mutation.
- Age
- Younger than 18 years at the time of leukemia diagnosis (0 to 17 years).
- Sex
- All sexes can join.
- Disease stage
- Acute leukemia that has relapsed or is refractory (did not respond to treatment).
- Earlier treatment
- Must have received menin inhibitor treatment under a Temporary Authorization for Use (ATU).
- Biomarker or test result
- KMT2A rearrangement, NUP98 rearrangement, or NPM1 mutation.
Main reasons for not taking part
- Received an ATU but did not receive the treatment
- Objected to the reuse of their data for scientific research
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 0 and 17 years old?
Source: NCT07898436, who can take part
Where in France
- Service de Pédiatrie 3 - Hôpital de Hautepierre - Hôpitaux Universitaires de Strasbourg - FranceStrasbourg, FranceContact: Catherine Paillard, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Hospital, Strasbourg, France
- Trial code
- NCT07898436
- Record updated
- 27 October 2026
- Original description
Acute leukemia is the most common childhood cancer. Despite advances in targeted therapies and immunotherapies, treatment remains challenging for children with relapsed or refractory acute leukemia, particularly those with KMT2A rearrangements, NPM1 mutations, or NUP98 rearrangements. Menin inhibitors have shown promising antileukemic activity in these molecular subgroups.Read full original descriptionShow less
Management of Relapsed or Refractory Acute Leukemia With Menin Inhibitors in Children: A French National Retrospective Study
Acute leukemia is the most common childhood cancer. Despite advances in targeted therapies and immunotherapies, treatment remains challenging for children with relapsed or refractory acute leukemia, particularly those with KMT2A rearrangements, NPM1 mutations, or NUP98 rearrangements. Menin inhibitors have shown promising antileukemic activity in these molecular subgroups.
This French national, multicenter, retrospective observational study will describe the pediatric population treated with menin inhibitors for relapsed or refractory acute leukemia. Clinical and biological data will be collected from the SACHA database for patients treated between February 1, 2020, and July 31, 2026. Approximately 10 patients are expected to be included. The study will describe patient and disease characteristics, treatment administration, safety, and efficacy, including remission status, minimal residual disease, relapse, and overall survival.
Inclusion: Patients with relapsed or refractory acute leukemia eligible for menin inhibitor treatment because of a KMT2A or NUP98 rearrangement or an NPM1 mutation; Patients who received menin inhibitor treatment under a Temporary Authorization for Use (ATU); Patients younger than 18 years at the time of acute leukemia diagnosis; Patients who have not objected to the reuse of their data for scientific research; Patients whose holders of parental authority have already provided authorization for the reuse of the child's data for scientific research.
Exclusion: Patients who received a Temporary Authorization for Use (ATU) but did not receive the treatment.