Green dye imaging checks bowel blood flow in rectal cancer surgery
Tests green dye imaging to assess bowel blood flow during rectal cancer surgery.
Plain-language title generated from the registry record
Registry title: FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer Surgery
Key facts
- Where
- Hyderabad, IndiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07899125, who can take part
Where in India
- Basavatarakam Indo American Cancer Hospital and Research InstituteHyderabad, IndiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Basavatarakam Indo American Cancer Hospital & Research Institute
- Trial code
- NCT07899125
- Record updated
- 27 October 2026
- Original description
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage from the surgical connection between two ends of the bowel.Read full original descriptionShow less
Fluorescent Angiography in Reduction of Anastomotic Leak in Rectal Cancer Surgery
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage from the surgical connection between two ends of the bowel.
The main questions this study aims to answer are:
* Does using ICG fluorescence imaging reduce the risk of leakage from the bowel connection after surgery? * Does ICG imaging help surgeons identify areas of the bowel with poor blood flow and decide whether the planned bowel connection needs to be changed?
Researchers will compare ICG fluorescence-guided assessment with conventional visual assessment of bowel blood flow during rectal cancer surgery.
Participants will:
* Undergo planned minimally invasive rectal cancer surgery as part of their treatment. * Be randomly assigned during surgery to either the ICG fluorescence imaging group or the standard care group. * Undergo postoperative imaging to check the bowel connection, usually around postoperative day 5 and approximately 4 weeks after surgery. * Be monitored for postoperative complications during their hospital stay and for 30 days after surgery. * Attend a follow-up assessment approximately 30 days after surgery.
Inclusion: Age 18 to 75 years, inclusive; Histologically confirmed rectal adenocarcinoma, treated with or without neoadjuvant therapy; Planned minimally invasive anterior rectal resection (laparoscopic or robotic) with anastomosis 2-15 cm from the anal verge, below the peritoneal reflection; Planned colorectal or coloanal anastomosis; Ability to provide written informed consent.
Exclusion: Emergency surgery or palliative procedure; Any serious contraindication to minimally invasive surgery; Planned open rectal surgery; Conversion from minimally invasive surgery to open surgery before randomization; Known allergy or hypersensitivity to indocyanine green (ICG) or iodine; Severe renal or hepatic failure; Intraoperative discovery of unresectable disease before randomization; Pregnancy or lactation; Inability to construct the planned colorectal or coloanal anastomosis before randomization.