Starting HIV prevention pills during an emergency room visit with a peer navigator
Tests starting daily HIV prevention medicine during an emergency visit, with peer support, in adults.
Plain-language title generated from the registry record
Registry title: Starting HIV Prevention Medicine (PrEP) During an Emergency Department Visit With a Peer Navigator
Key facts
- Where
- Tampa, United StatesSee the site
- Phase
- Phase 4
Where in United States
- Tampa General HospitalTampa, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of South Florida
- Trial code
- NCT07901101
- Record updated
- 28 October 2026
- Original description
The goal of this study is to learn whether adults who visit a hospital emergency department (ED) find it acceptable to start HIV pre-exposure prophylaxis (PrEP) during that same visit, with help from a peer navigator. PrEP is a daily pill that lowers the chance of getting HIV. Many people who could benefit from PrEP use the ED for health care but have no regular doctor, so they may never be offered it.Read full original descriptionShow less
RAPID Response (Revolutionary Access to PrEP In the ED): A Pilot Implementation Study of Peer Navigator-Facilitated, Same-Visit Initiation of Oral HIV Pre-Exposure Prophylaxis in the Emergency Department
The goal of this study is to learn whether adults who visit a hospital emergency department (ED) find it acceptable to start HIV pre-exposure prophylaxis (PrEP) during that same visit, with help from a peer navigator. PrEP is a daily pill that lowers the chance of getting HIV. Many people who could benefit from PrEP use the ED for health care but have no regular doctor, so they may never be offered it.
The main questions this study aims to answer are:
* Do participants find starting PrEP in the ED acceptable? * How many participants take the first dose, connect with an ongoing PrEP provider, and keep taking PrEP over one year?
At Tampa General Hospital, a peer PrEP navigator (a trained study team member) will offer PrEP information to adults in the ED. Adults who agree to join the study and test HIV-negative will:
* take their first PrEP pill in the ED while the navigator watches, and leave with a 29-day supply at no cost * choose a community PrEP provider for ongoing care, with help from the navigator * answer short surveys before leaving the ED and by phone at 2-3 days, 30 days, 60 days, 90 days, and 1 year * allow the navigator to confirm follow-up PrEP lab work with their outside provider at about 120 days
Inclusion: Age 18 years or older; Patient in the Tampa General Hospital emergency department; Negative fourth-generation HIV antigen/antibody test during the emergency department visit; Medically stable and able to take part in education; Able to provide informed consent.
Exclusion: Currently taking PrEP, or took PrEP in the last 3 months; Received injectable PrEP in the last 12 months; Positive or indeterminate HIV test result; Signs or symptoms of acute (recent) HIV infection; Active hepatitis B infection; Known allergy to tenofovir or emtricitabine; Creatinine clearance below 60 mL/min.