Using Scan Images to Detect Vessel Wall Invasion in Kidney Cancer With Tumor Thrombus
Tests whether scan images can show vena cava wall invasion in kidney cancer.
Plain-language title generated from the registry record
Registry title: Habitat Analysis of Tumor Thrombus for Vena Cava Wall Invasion in Renal Cell Carcinoma
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- Peking University Third HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Liu Zhuo
- Trial code
- NCT07901569
- Record updated
- 28 October 2026
- Original description
Tumor thrombus in the inferior vena cava can invade the vessel wall. Doctors must know the invasion status before surgery. The status changes the surgical plan. Preoperative imaging has limited accuracy for wall invasion. Habitat imaging divides a tumor into subregions. Each subregion is a habitat. The method uses voxel-level image features.Read full original descriptionShow less
HABITAT: Habitat Analysis of Tumor Thrombus Boundary for Invasion Assessment With Transcriptomic Analysis of Tissue - a Diagnostic Accuracy and Spatial Transcriptomic Validation Study in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus
Tumor thrombus in the inferior vena cava can invade the vessel wall. Doctors must know the invasion status before surgery. The status changes the surgical plan. Preoperative imaging has limited accuracy for wall invasion. Habitat imaging divides a tumor into subregions. Each subregion is a habitat. The method uses voxel-level image features.
This study will test whether habitat imaging can diagnose inferior vena cava wall invasion. The participants have renal cell carcinoma with renal vein or inferior vena cava tumor thrombus. The study will use existing preoperative contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) images. The reference standard is the pathology report from surgery.
The primary measurement is the area under the receiver operating characteristic curve (AUROC) of the habitat model for wall invasion. The study will also measure sensitivity, specificity, calibration, and clinical utility. In an exploratory analysis, the study will compare imaging habitats with spatial transcriptomic regions. The study will use available Visium data from two participants.
This is a retrospective observational study. The study has no intervention. The study will not change clinical care. The results will show whether habitat imaging can support preoperative planning.
Inclusion: The participant is 18 years or older at surgery; The participant had radical nephrectomy with tumor thrombectomy at the study center; The participant had renal cell carcinoma with renal vein or inferior vena cava tumor thrombus; The pathology report confirms renal cell carcinoma. Any histological subtype is eligible; The participant has a preoperative contrast-enhanced computed tomography (CT) or MRI image. The CT/MRI phase is complete. The image has no severe artifact that prevents segmentation; The participant has a surgical pathology report. The report states the inferior vena cava wall invasion status.
Exclusion: The surgical pathology report is missing. The report does not state the wall invasion status; The reader cannot delineate the tumor thrombus on the image. The study team will report this case as an independent failure reason. The team will not merge this case with missing data; The pathology report shows a non-renal-cell-carcinoma histology. Examples are urothelial carcinoma, renal pelvic carcinoma, angiomyolipoma, and adrenocortical carcinoma; The preoperative contrast-enhanced CT/MRI image is missing or not adequate. Examples are no contrast phase, severe artifact, or no segmentable image.