Comparing two epidural pain medicine combinations after major open abdominal surgery
Compares ropivacaine with fentanyl or morphine for pain relief after major abdominal surgery.
Plain-language title generated from the registry record
Registry title: Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Key facts
- Where
- Athens, GreeceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having planned (elective) open abdominal surgery. It compares two pain-relief mixtures given through an epidural after the operation.
- Age
- 18 to 80 years
- Sex
- All sexes
- Disease stage
- Planned (elective) open abdominal surgery
Main reasons for not taking part
- Blood clotting disorders
- Demyelinating disorders of the central nervous system
- Severe unstable blood pressure needing vasopressors from the start of surgery
- Reported allergic reaction to local anaesthetics
- Objection to taking part
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07901582, who can take part
Where in Greece
- Evangelismos General HospitalAthens, GreeceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National and Kapodistrian University of Athens
- Trial code
- NCT07901582
- Record updated
- 30 October 2026
- Original description
Introduction:Read full original descriptionShow less
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction:
Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent advancement in the field.Despite this improvement,postoperative pain continues to be a challenge since suboptimal postoperative pain control is a risk factor for persistent surgical pain,increased morbidity,poorer functional recovery and reduced quality of life.Therefore,analgesic strategies should regard patients' factors as well as surgical procedures peculiarities.Since efforts are made throughout the years and are of utmost importance as numerous analgesic options exist for the effective pain control after abdominal surgeries including multiple classes of drugs and routes of administration(i.e.parenteral,regional,neuraxia.)In the context of the current surgical environment where improvement has been made,emphasis is placed on precision,minimizing trauma and improving the outcome.The choice of postoperative pain analgesic modality,is at the discretion of the primary anaesthesiologist and the choice depends upon the plan favored by him/her as well as the availability of drugs and equipment.Continuous re-evaluation of analgesic strategies is a necessary step toward establishing a better pain management plan in major abdominal surgeries and to design guidelines to improve our clinical approach.
Study Objective:
The target of the study is to compare the outcome of the selected analgesic combination of local anaesthetic and opioid(ropivacaine+fentanyl or ropivacaine +morphine)for postoperative continuous infusion,aiming to relief successfully the pain,on patients undergoing major abdominal surgeries based on hemodynamic and clinical findings.
The study aims to highlight the positive impact of the chosen analgesic combination during the intraoperative period,the postoperative recovery period and also during the follow up periods in terms of physical function,pain intensity during activity,adverse effects and self efficacy.
Methods:
The study is prospective,comparative aiming to identify the pain management agents that will provide the best postoperative relief in order to be established and used as a primary choice to patients undergoing major open abdominal surgeries .All patients included will receive the same analgesic technique(epidural)chosen preoperatively by the anaesthesiologist in charge.All study participants are informed in detail and written informed consent is obtained.The study is in accordance with the regulations of the Declaration of Helsinki on human studies and the Greek legislation.
The investigators will study 58 patients,equally divided into two groups, aged 18-80 years,administered to Evangelismos General hospital,Athens-Greece, for elective open abdominal surgeries.
In group A(p:29),the investigators will administer for postoperative pain relief - Ropivacaine 200 ml/400 mg + Fentanyl for continuous epidural infusion for the first 5 days.The infusion will start 2 hours before the end of the operation and before the admission to the intensive care unit.
In group B(p:29),the investigators will administer for postoperative pain relief Ropivacaine 200ml/400mg + Morphine for continuous epidural infusion for the first 5 days.The infusion will start 2 hours before the end of the operation and before the admission to the intensive care unit.
Inclusion: Elective surgical patients admitted for open abdominal surgeries; -.
Exclusion: Coagulation disorders. Demyelinating disorders of the CNS. Severe hemodynamic instability requiring vasopressors from the early beginning of the surgery. Reported allergic reaction to local anaesthetics Objection to take part; -.