Two exercise programs for people with moderate chronic kidney disease not on dialysis
Compares two supervised exercise programs in adults with chronic kidney disease, not on dialysis.
Plain-language title generated from the registry record
Registry title: Combined Versus Multicomponent Training in People With Chronic Kidney Disease Stages 3a and 3b
Key facts
- Where
- Brasília, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 55 and 70 years old?
Source: NCT07901621, who can take part
Where in Brazil
- University of Brasilia - Faculty of Physical Education and Olympic CenterBrasília, BrazilNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Brasilia
- Trial code
- NCT07901621
- Record updated
- 30 October 2026
- Original description
This randomized controlled trial will compare the effects of 12 weeks of combined training (aerobic plus resistance exercise) and multicomponent training (aerobic plus resistance plus balance exercise) with a control group without supervised exercise in adults aged 55 to 70 years with chronic kidney disease (CKD) stages 3a or 3b who are not on dialysis. Fifty-seven participants will be randomly allocated (1:1:1) to one of the three groups. Supervised training sessions will last 60 minutes and will be held three times a week at the University of Brasilia, Brazil. The main questions are whether these programs improve peak oxygen uptake, resting blood pressure, physical health-related quality of life, and estimated glomerular filtration rate, and whether adding balance exercises provides additional benefits for balance, falls, and functional capacity.Read full original descriptionShow less
Effects of Combined and Multicomponent Training on Physiological, Functional, and Quality of Life Parameters in People With Chronic Kidney Disease: A Randomized Controlled Clinical Trial
This randomized controlled trial will compare the effects of 12 weeks of combined training (aerobic plus resistance exercise) and multicomponent training (aerobic plus resistance plus balance exercise) with a control group without supervised exercise in adults aged 55 to 70 years with chronic kidney disease (CKD) stages 3a or 3b who are not on dialysis. Fifty-seven participants will be randomly allocated (1:1:1) to one of the three groups. Supervised training sessions will last 60 minutes and will be held three times a week at the University of Brasilia, Brazil. The main questions are whether these programs improve peak oxygen uptake, resting blood pressure, physical health-related quality of life, and estimated glomerular filtration rate, and whether adding balance exercises provides additional benefits for balance, falls, and functional capacity.
Inclusion: CKD stage 3a or 3b (eGFR 30-59 mL/min/1.73 m2) according to KDIGO 2024, diagnosed at least 6 months before enrollment; Age between 55 and 70 years; Body mass index between 18.5 and 35 kg/m2; No participation in a structured exercise program in the previous 3 months; Controlled systemic arterial hypertension and/or type 2 diabetes mellitus are allowed; No clinical contraindication to exercise training or to the study assessments; Literacy sufficient to understand the informed consent form and questionnaires.
Exclusion: CKD stages 1, 2, 4, or 5, dialysis, or kidney transplantation; Concurrent participation in another supervised exercise program; Polycystic kidney disease; Congestive heart failure, advanced chronic obstructive pulmonary disease, heart disease, arrhythmias, unstable angina, or type 1 diabetes mellitus; Dementia or psychiatric disorders that compromise understanding of instructions or safe exercise; Musculoskeletal injuries or neurological disorders that prevent participation in the exercise program.