The Effect of Theory-driven Physiotherapy on Physical Activity in Knee OA.
Key facts
- Where
- Rotterdam, NetherlandsSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 70 years old?
Source: NCT07901881, who can take part
Where in Netherlands
- Rotterdam University of Applied ScienceRotterdam, NetherlandsContact: Mark van Loo, MSc.No longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Mark van Loo
- Trial code
- NCT07901881
- Record updated
- 28 October 2026
- Original description
Knee osteoarthritis (OA) is a leading cause of pain, disability, and reduced physical functioning worldwide. Although physiotherapy and physical activity are recommended as first-line treatments, many individuals with knee OA do not achieve or maintain recommended levels of physical activity. As a result, the benefits of evidence-based physiotherapy are often not fully realized. To improve physical activity participation, effective behaviour change interventions are needed.Read full original descriptionShow less
What is the Effect of Theory-driven Physiotherapy on Physical Activity in People With Knee Osteoarthritis: A Multiple Baseline Single-case Experimental Design Study.
Knee osteoarthritis (OA) is a leading cause of pain, disability, and reduced physical functioning worldwide. Although physiotherapy and physical activity are recommended as first-line treatments, many individuals with knee OA do not achieve or maintain recommended levels of physical activity. As a result, the benefits of evidence-based physiotherapy are often not fully realized. To improve physical activity participation, effective behaviour change interventions are needed.
Theory-informed interventions have the potential to enhance physiotherapy outcomes by targeting the psychological determinants that influence physical activity behaviour. One well-established framework is the Theory of Planned Behaviour (TPB), which proposes that behaviour is primarily influenced by behavioural intention, attitude, subjective norms, and perceived behavioural control. To translate these determinants into intervention content, behaviour change techniques (BCTs) can be systematically selected using tools such as the Behaviour Change Intervention Ontology (BCIO), Mechanisms of Action Ontology (MoAO), and Theory and Techniques Tool (TaTT). This approach may improve the effectiveness and sustainability of behaviour change interventions.
The present study therefore aims to evaluate the potential of a TPB-based behaviour change intervention as an addition to guideline-recommended physiotherapy for individuals with knee OA. The primary objective is to determine whether this theory-driven intervention can improve physical activity levels and reduce sedentary behaviour. A secondary objective is to explore the behavioural mechanisms through which these changes occur.
The study will employ a randomized, concurrent, multiple-baseline single-case experimental design (SCED). Participants with knee OA will receive a six-week physiotherapy intervention consisting of usual guideline-based care supplemented with a TPB-based behaviour change component. Physical activity and sedentary behaviour will be continuously assessed using ActiGraph accelerometers. In addition, behavioural determinants, pain, and functional limitations will be repeatedly measured to evaluate potential mechanisms of action and clinical effects. Findings from this study may contribute to the development of more effective, theory-informed physiotherapy interventions aimed at promoting sustainable physical activity behaviour in people with knee OA.
Inclusion: 45-70 years of age,; knee osteoarthritis in accordance with the National Institute for Health and Care Excellence (NICE) guideline: people who i) have activity related joint pain and ii) have no or brief (≤ 30 min.) morning stiffness of the affected joint; there is an indication for guided exercise therapy (treatment indication 2 or 3 from the Osteoarthritis guideline of the Royal Dutch Society for Physical Therapy) and; are able to read and understand Dutch.
Exclusion: recent surgery (within the last 3 months) of the affected joint,; having had joint replacement surgery (at the side of the current pain problem); known cardiovascular disease,; known neurological or psychiatric disorder,; already performs ≥150 minutes of moderate physical activity per week,; rheumatoid arthritis,.