NCT07902011Not yet recruiting
CTEPH Differential Diagnosis Assisted by Enhanced Large Language Model Support
Large Language Model-Assisted Differential Diagnosis of Pulmonary Artery Filling Defects: A Stratified Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
This randomized controlled trial aims to evaluate whether a locked large language model (LLM)-based clinical decision support system improves the differential diagnosis of pulmonary artery filling defects among physicians who do not specialize in pulmonary vascular diseases. Participants will evaluate 30 de-identified clinical cases involving chronic thromboembolic pulmonary hypertension (CTEPH), acute pulmonary embolism (PE), and pulmonary artery sarcoma (PAS), with or without LLM assistance. The primary outcome is sensitivity for identifying CTEPH, while secondary outcomes include overall diagnostic accuracy, time to diagnosis, appropriateness of referral recommendations, and AI-related diagnostic errors.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 22 Oct 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- China-Japan Friendship Hospital
- NCT number
- NCT07902011
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Oct 2026 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has a specialist professional background in pulmonary vascular disease, pulmonary hypertension, or thoracic imaging.
Other
- Participated in validation-case selection, reference-standard confirmation, model development, prompt optimization, or review of locked model outputs.
- Is unable to use the standardized platform or to comply with independent case interpretation and the prohibition on external generative AI tools.
- Has another circumstance that, in the investigator's judgment, could materially compromise independent case interpretation.
Who the study is looking for
- Holds a valid physician qualification, or is enrolled in a standardized residency training program and is permitted to participate in clinical care under supervision.
- Has not previously reviewed the validation cases or their final diagnoses.
- Is willing to participate and provides informed consent.
- Is able to use the standardized study platform and complete two formal case-reading sessions covering all 30 cases.
Criteria the registry did not label
- The study participants are clinicians; patients represented in the de-identified case materials are not enrolled as study participants.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| China-Japan Friendship Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.