Comparing Ways to Collect Germ Samples in Children With Chronic Lung Disease
Compares throat suction with other samples in children with cystic fibrosis or bronchiectasis.
Plain-language title generated from the registry record
Registry title: Diagnostic Value of Oropharyngeal Suction and Effect of Respiratory Physiotherapy on the Detection of Microorganisms in the Pediatric Patient
Key facts
- Where
- Sabadell, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and teenagers aged 5 to 18 with a long-term lung disease who need a sputum sample. It compares three ways of taking samples and tests whether a physiotherapy session before sampling helps.
- Age
- 5 to 18 years
- Sex
- All sexes can join.
- Disease stage
- A long-term (chronic) lung disease that requires a sputum sample. The conditions listed are cystic fibrosis and bronchiectasis not caused by cystic fibrosis.
- Earlier treatment
- Cannot have taken antibiotics in the previous week. Children on long-term azithromycin treatment are the exception.
Main reasons for not taking part
- Severe acute infection that makes any of the procedures unsafe, for example severe breathing failure or shock
- Antibiotics taken in the previous week (except long-term azithromycin)
- Decompensated heart and lung disease
- Past severe reaction to hypertonic saline nebulization
- Not able to cooperate in the physiotherapy session or not agreeing to the procedures
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 5 and 18 years old?
Source: NCT07903792, who can take part
Where in Spain
- Corporacio Sanitaria Parc TauliSabadell, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Corporacion Parc Tauli
- Trial code
- NCT07903792
- Record updated
- 29 October 2026
- Original description
The goal of this clinical trial is to determine the effectiveness of oropharyngeal suction in detecting microorganisms by comparing it with induced sputum and oropharyngeal swab samples. It also aims to assess the effect of respiratory physiotherapy on improving the results obtained in children aged 5-18 years with chronic lung disease.Read full original descriptionShow less
Diagnostic Value of Oropharyngeal Suction Compared With Induced Sputum and Oropharyngeal Swab, and the Effect of Respiratory Physiotherapy on the Detection of Microorganisms in Paediatric Patients With Chronic Respiratory Disease: a Randomized Clinical Trial
The goal of this clinical trial is to determine the effectiveness of oropharyngeal suction in detecting microorganisms by comparing it with induced sputum and oropharyngeal swab samples. It also aims to assess the effect of respiratory physiotherapy on improving the results obtained in children aged 5-18 years with chronic lung disease.
The main questions it aims to answer are:
* What is the diagnostic efficacy of oropharyngeal suction in detecting microorganisms compared with induced sputum? * What is the effect of undergoing a physiotherapy session before sample collection? * How do the results obtained from oropharyngeal suction correlate with those obtained from oropharyngeal swabs? * How does the age of the participants affect the results obtained from each sampling technique and the effect of prior physiotherapy? * Are these techniques safe?
Researchers will compare samples collected after a physiotherapy session with those collected without prior physiotherapy to determine whether physiotherapy improves culture results.
Participants will be randomized into two groups: one group will undergo a physiotherapy session before sample collection, while the other will not. Three samples will be collected from each participant using oropharyngeal suction, an oropharyngeal swab, and induced sputum. Each participant may take part on multiple occasions, provided that at least one month has elapsed since their previous participation. On each occasion, participants will be randomized again.
Inclusion: Having a chronic respiratory disease that requires sputum sample collection; Being able to cooperate during the physiotherapy session; Having provided signed informed consent.
Exclusion: Having taken antibiotics in the previous week, except for patients receiving chronic azithromycin treatment; Severe acute infection that contraindicates any of the procedures (e.g., severe respiratory failure, shock, etc.); Decompensated cardiorespiratory disease; History of severe adverse reactions to hypertonic saline nebulization; Patients who do not consent to or are unable to undergo the procedures.