The Effect of Different Exercise Training Programs on Muscle Oxygenation in Individuals With Knee Osteoarthritis
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 65 years old?
Source: NCT07904741, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Bahçeşehir University
- Trial code
- NCT07904741
- Record updated
- 29 October 2026
- Original description
Knee osteoarthritis can cause pain, reduced muscle strength, and difficulty with daily activities. Exercise is commonly used to manage knee osteoarthritis, but the effects of different exercise programs on muscle oxygenation are not fully understood.Read full original descriptionShow less
The Effect of Different Exercise Training Programs on Muscle Oxygenation, Strength, Pain, and Functionality in Individuals With Knee Osteoarthritis
Knee osteoarthritis can cause pain, reduced muscle strength, and difficulty with daily activities. Exercise is commonly used to manage knee osteoarthritis, but the effects of different exercise programs on muscle oxygenation are not fully understood.
This study will compare three 6-week exercise programs in adults with knee osteoarthritis: aerobic exercise on a recumbent bicycle, lower-limb strengthening exercise, and a program combining aerobic and strengthening exercise. Participants will be randomly assigned to one of the three groups. Each group will attend three supervised exercise sessions weekly for 6 weeks. All participants will also receive a home stretching program. Participants will be assessed before the program, at weeks 3 and 6, and again at week 10, after a 4-week period without supervised exercise.
The study will examine whether the exercise programs improve muscle oxygenation and whether changes in muscle oxygenation are associated with changes in muscle strength, pain, and physical function. The investigators expect muscle oxygenation to improve after the exercise programs and expect these changes to be associated with improvements in clinical measures.
Inclusion: Age 45 to 65 years; Body mass index (BMI) below 30 kg/m²; Physician-diagnosed knee osteoarthritis according to the American College of Rheumatology (ACR) criteria; Bilateral knee osteoarthritis of Kellgren-Lawrence grade 2 or 3; Willingness to participate and provide informed consent.
Exclusion: Treatment for knee osteoarthritis within the previous 6 months, including physical therapy or injection; Orthopedic or rheumatologic disease of the lower extremities, or arterial or venous disease; Uncontrolled hypertension, pulmonary disease, or diabetes; Neurological disease; Learning or cognitive impairment that may prevent participation; Knee extension deficit; Physical activity level above 600 MET-minutes/week, assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF).