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A resilience and stress skills program for teens with Tourette syndrome

Tests a stress-management skills program in teens with Tourette syndrome or persistent tic disorders.

Key facts

Who runs it
Wake Forest University Health Sciences
Where
Winston-Salem, United StatesSee the site
Trial code
Registry title
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
Status
Not yet recruiting
People taking part
95 people, planned
Started
Nov 2026
Expected to end
Jun 2031
Type of study
Interventional, 4 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • PRISM Intervention
  • Usual care intervention
Record updated
30 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for teens aged 12-18 with Tourette syndrome or a persistent tic disorder. They would try a short skills program called PRISM that teaches resilience and stress management.

Age
12 to 18 years
Sex
All sexes can join.
Disease stage
A doctor-confirmed Tourette syndrome or persistent (chronic) motor or vocal tic disorder, with a tic severity score (YGTSS Total Tic Severity) of at least 15 for Tourette syndrome, or a Total Motor/Total Phonic score of at least 10 for a persistent motor or vocal tic disorder. The YGTSS Impairment score must be at least 20.
Earlier treatment
People cannot join if they begin any new therapy within 8 weeks of the study start.

Main reasons for not taking part

  • An active diagnosis of functional neurological disorder
  • Beginning any new therapy within 8 weeks of study start
  • Not fluent in reading and speaking English
  • Not able to understand and complete study procedures and measures

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Age 12-18 years
  • Physician-confirmed diagnosis of Tourette syndrome or persistent (chronic) motor or vocal tic disorder per DSM-5-TR criteria
  • YGTSS Total Tic Severity ≥15 (Tourette syndrome) or Total Motor/Total Phonic score ≥10 (persistent motor or vocal tic disorder)
  • YGTSS Impairment ≥20
  • English fluency in reading and speaking, even as a second language
  • Able to understand and complete study procedures and measures

Who cannot take part

  • Beginning any new therapy within 8 weeks of study initiation
  • An active diagnosis of functional neurological disorder

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 12 and 18 years old?

Where in United States

  • Atrium Health Wake Forest BaptistWinston-Salem, United StatesContact: Carolina Burgos-Aguilar, MSNot yet recruiting

About the trial

What the trial wants to find out

This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder. The study has three parts. First, a small group of teens and their caregivers try PRISM and give feedback to adapt it for teens with tics. Second, 15 teens complete the adapted program to see whether it is practical and acceptable. Third, 60 teens are randomly assigned to PRISM plus usual care or usual care alone, to see whether a larger trial is feasible and to get early information on resilience and other outcomes.

The 4 groups in the trial

  • Aim 1: Co-adaptation focus group (n=10 + caregivers)Other group

    PRISM Skills 1-4 (delivered by the PRISM team), each followed by a feedback interview

    Treatment: PRISM Intervention

  • Aim 2: Open trial (n=15)Treatment being tested

    Adapted PRISM

    Treatment: PRISM Intervention

  • Aim 3: PRISM + usual care (n=30)Treatment being tested

    Adapted PRISM; Usual care

    Treatment: PRISM Intervention

  • Aim 3: Usual care (n=30)Existing treatment, for comparison

    Usual care; study-team check-ins matched to the PRISM schedule

    Treatment: Usual care intervention

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Adapting and Pilot Testing Promoting Resilience in Stress Management (PRISM) for Adolescents With Tourette Syndrome and Persistent Tic Disorders: A Mixed-Methods Feasibility Study and Pilot Randomized Controlled Trial
Plain-language title
A resilience and stress skills program for teens with Tourette syndromeGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 13 November 2026.
Fit questions
Built from NCT07905898, who can take part
Record updated
30 October 2026