Malnutrition and Muscle Loss in Tunisian Adults With Chronic Kidney Disease
Observes how common malnutrition and muscle loss are in Tunisian adults with kidney disease.
Plain-language title generated from the registry record
Registry title: Malnutrition and Sarcopenia in Adults With Chronic Kidney Disease in Tunisia
Key facts
- Where
- Tunis, TunisiaSee the site
Where in Tunisia
- Hôpital Militaire Principal d'Instruction de Tunis, Department of NephrologyTunis, TunisiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Dacima Consulting
- Trial code
- NCT07906405
- Record updated
- 30 October 2026
- Original description
The TUN-CKDN study is a national, multicenter, prospective cohort study conducted in nephrology centers in Tunisia. It aims to describe how often malnutrition and sarcopenia (loss of muscle strength and muscle mass) occur in adults with chronic kidney disease (CKD) stages G3a to G5D, including patients not on dialysis and patients treated by hemodialysis or peritoneal dialysis, and whether these conditions are linked to future health outcomes.Read full original descriptionShow less
Nutritional Status, Muscle Phenotype, and Clinical Outcomes in Tunisian Patients With Chronic Kidney Disease: a National Multicenter Prospective Cohort Study (TUN-CKDN)
The TUN-CKDN study is a national, multicenter, prospective cohort study conducted in nephrology centers in Tunisia. It aims to describe how often malnutrition and sarcopenia (loss of muscle strength and muscle mass) occur in adults with chronic kidney disease (CKD) stages G3a to G5D, including patients not on dialysis and patients treated by hemodialysis or peritoneal dialysis, and whether these conditions are linked to future health outcomes.
At inclusion, each participant will undergo a standardized nutritional and muscle assessment as part of routine care: medical history, physical activity questionnaire, clinical examination, body weight and height, body composition by bioelectrical impedance analysis (or calf circumference when impedance cannot be performed), a chair-stand test for muscle strength, a 4-meter walking speed test, routine blood tests, and a detailed dietary interview conducted by a trained dietitian. Malnutrition will be defined using the Global Leadership Initiative on Malnutrition (GLIM) criteria and sarcopenia using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. The Malnutrition-Inflammation Score (MIS) will also be calculated.
Participants available at 2 years will have the same nutritional and muscle assessment repeated. All participants will be followed at 2 and 5 years to record kidney outcomes (start of dialysis or kidney transplantation in patients not on dialysis at inclusion), major cardiovascular events, hospitalizations, and deaths.
The study does not involve any treatment or change in usual medical care. About 4,000 participants are planned.
Inclusion: Age 18 years or older; Chronic kidney disease known for at least 3 months; Chronic kidney disease stage G3a, G3b, G4, G5 not receiving dialysis, or G5D (maintenance hemodialysis or peritoneal dialysis); Followed at one of the participating centers; Signed informed consent.
Exclusion: Kidney transplant recipient; Severe acute clinical condition requiring hospitalization at the time of inclusion; Inability to provide informed consent; Pregnancy.