NCT07906769Recruiting
Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models
Analisi Automatizzata Del Linguaggio Nelle Malattie Neurodegenerative: Applicazione di Modelli di Intelligenza Artificiale
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This multicenter study aims to characterize the language profiles of patients with various neurodegenerative diseases, including Alzheimer's disease (AD), Primary Progressive Aphasia (PPA), behavioral variant Frontotemporal Dementia (bvFTD), Dementia with Lewy Bodies (DLB), and Parkinson's disease (PD), using artificial intelligence (AI) models. By analyzing speech and language data collected during remote neuropsychological assessments, the researchers intend to identify objective linguistic biomarkers suitable for early and differential diagnosis, overcoming the limitations of traditional, invasive, and costly diagnostic tools. The project will develop and validate an AI-driven pipeline to provide scalable and individualized linguistic profiles, ultimately supporting personalized treatment strategies and improving clinical workflow efficiency in the Italian population.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 26 Oct 2026
- Start date
- 20 Oct 2025
- Primary completion date
- 31 Jan 2028
- Lead sponsor
- Istituti Clinici Scientifici Maugeri SpA
- NCT number
- NCT07906769
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 20 Oct 2025 to the primary completion date, 31 Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other neurological or psychiatric diagnoses, including cerebrovascular disease documented by MRI or CT.
- Severe, uncorrected hearing or visual impairment.
- Clinical Dementia Rating (CDR) score above 1.
- Healthy controls
- History of systemic, neurological, or psychiatric disease.
- Family history of neurodegenerative disease.
Other
- Mini-Mental State Examination (MMSE) score below 15.
- Substance abuse.
- MMSE score below 27/30.
Who the study is looking for
- Diagnosis of mild cognitive impairment due to Alzheimer's disease (AD), primary progressive aphasia (PPA), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB), or Parkinson's disease (PD).
- Age 40-85 years.
- Italian native speaker.
- Able to provide informed consent.
- Italian native speaker.
- Matched to the patient groups for age, sex, and education level.
Criteria the registry did not label
- Participants with neurodegenerative diseases
Age in the registry: 40 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istituti Clinici Scientifici Maugeri IRCCS Bari Coordinator of this site? Confirm its status | Bari | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.