Using AI to analyze speech in Alzheimer's, Parkinson's and other dementias
Tests whether AI analysis of speech can help diagnose neurodegenerative diseases early.
Plain-language title generated from the registry record
Registry title: Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models
Key facts
- Where
- Bari, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 90 years old?
Source: NCT07906769, who can take part
Where in Italy
- Istituti Clinici Scientifici Maugeri IRCCS BariBari, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituti Clinici Scientifici Maugeri SpA
- Trial code
- NCT07906769
- Record updated
- 3 November 2026
- Original description
This multicenter study aims to characterize the language profiles of patients with various neurodegenerative diseases, including Alzheimer's disease (AD), Primary Progressive Aphasia (PPA), behavioral variant Frontotemporal Dementia (bvFTD), Dementia with Lewy Bodies (DLB), and Parkinson's disease (PD), using artificial intelligence (AI) models. By analyzing speech and language data collected during remote neuropsychological assessments, the researchers intend to identify objective linguistic biomarkers suitable for early and differential diagnosis, overcoming the limitations of traditional, invasive, and costly diagnostic tools. The project will develop and validate an AI-driven pipeline to provide scalable and individualized linguistic profiles, ultimately supporting personalized treatment strategies and improving clinical workflow efficiency in the Italian population.Read full original descriptionShow less
Analisi Automatizzata Del Linguaggio Nelle Malattie Neurodegenerative: Applicazione di Modelli di Intelligenza Artificiale
This multicenter study aims to characterize the language profiles of patients with various neurodegenerative diseases, including Alzheimer's disease (AD), Primary Progressive Aphasia (PPA), behavioral variant Frontotemporal Dementia (bvFTD), Dementia with Lewy Bodies (DLB), and Parkinson's disease (PD), using artificial intelligence (AI) models. By analyzing speech and language data collected during remote neuropsychological assessments, the researchers intend to identify objective linguistic biomarkers suitable for early and differential diagnosis, overcoming the limitations of traditional, invasive, and costly diagnostic tools. The project will develop and validate an AI-driven pipeline to provide scalable and individualized linguistic profiles, ultimately supporting personalized treatment strategies and improving clinical workflow efficiency in the Italian population.
Inclusion: Diagnosis of mild cognitive impairment due to Alzheimer's disease (AD), primary progressive aphasia (PPA), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB), or Parkinson's disease (PD); Age 40-85 years; Italian native speaker; Able to provide informed consent; Italian native speaker; Matched to the patient groups for age, sex, and education level.
Exclusion: Other neurological or psychiatric diagnoses, including cerebrovascular disease documented by MRI or CT; Severe, uncorrected hearing or visual impairment; Clinical Dementia Rating (CDR) score above 1; Healthy controls; History of systemic, neurological, or psychiatric disease; Family history of neurodegenerative disease; Mini-Mental State Examination (MMSE) score below 15; Substance abuse; MMSE score below 27/30.
Participants with neurodegenerative diseases.