Strength and thinking exercises for muscle loss in Parkinson's disease
Compares exercise programs against education for muscle loss in adults with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Strength and Dual-Task on Sarcopenia in People With Parkinson's Disease
Key facts
- Where
- Valencia, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07907302, who can take part
Where in Spain
- Clínica NYRValencia, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Valencia
- Trial code
- NCT07907302
- Record updated
- 30 October 2026
- Original description
Parkinson´s disease and parkinsonian syndromes are associated with progressive motor and non-motor impairments that may compromise functional independence and quality of life. Sarcopenia, characterized by reduced muscle strength, muscle mass, and physical performance, is highly prevalent in these populations and may contribute to an increased risk of falls, frailty, and disability.Read full original descriptionShow less
Effects of a Multimodal Strength and Dual-Task Program on Sarcopenia and Functional Performance in People With Parkinson's Disease and Parkinsonian Syndromes
Parkinson´s disease and parkinsonian syndromes are associated with progressive motor and non-motor impairments that may compromise functional independence and quality of life. Sarcopenia, characterized by reduced muscle strength, muscle mass, and physical performance, is highly prevalent in these populations and may contribute to an increased risk of falls, frailty, and disability.
This prospective, parallel-group, three-arm randomized controlled trial aims to compare the effects of three levels of physiotherapy intervention on sarcopenia-related parameters and physical function in adults with Parkinson´s disease or parkinsonian syndromes.
The Education Group will receive standarized nutritional education and general physical exercise recommendations through structed educational materials, without supervised exercise training. The Progressive Resistance Training (PRT) Group will receive standarized nutritional education and participate in supervised progressive resistance trained combined with cognitive dual-task exercises. The PRT plus Instability Group will receive the same nutritional education, progressive resistance training, and cognitive dual-task training, with additional instability and postural control components. Participants in the two supervised exercise groups will complete two physiotherapy sessions per week for 12 weeks.
Assessments will be conducted at baseline (T0), immediately after the 12-week intervention (T1), and four weeks after completion of the intervention (T2). Outcomes will include clinical and functional status, muscle strength, body composition and other sarcopenia-related measures, physical performance, nutritional status, neurocognitive status, number of falls, and Parkinson's disease-related clinical characteristics.
The study will evaluate the effects of supervised progressive resistance training compared with an educational intervention and will explore whether adding instability and postural control demands to progressive resistance training provides additional effects on physical function, sarcopenia-related outcomes, and fall-related functional risk in people with Parkinson's disease and parkinsonian syndromes.
Inclusion: Clinical diagnosis of Parkinson's disease or parkinsonism confirmed by a neurologist; Hoehn and Yahr stage 1-3; Age ≥18 years; Stable antiparkinsonian drug treatment for at least the previous 4 weeks; Ability to ambulate independently, with or without assistive devices; Ability to understand and follow basic safety instructions.
Exclusion: Other neurological diseases that interfere with the assessment; Any medical condition that contraindicates supervised physical exercise; Severe or uncontrolled additional pathology; Recent fractures; Severe dyskinesias or unpredictable motor fluctuations that compromise safety.