Acupuncture added to vitamin B12 for heart nerve damage in type 2 diabetes
Tests acupuncture plus mecobalamin in adults with type 2 diabetes and heart nerve damage.
Plain-language title generated from the registry record
Registry title: Acupuncture Plus Mecobalamin for Diabetic Cardiac Autonomic Neuropathy
Key facts
- Where
- Nanjing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT07907536, who can take part
Where in China
- Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityNanjing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Trial code
- NCT07907536
- Record updated
- 30 October 2026
- Original description
The goal of this clinical trial is to learn whether acupuncture can improve damage to the nerves that control the heart (cardiac autonomic neuropathy) in adults with type 2 diabetes. It will also learn about the safety of this acupuncture treatment.Read full original descriptionShow less
Efficacy and Safety of Acupuncture at Xinshu (BL15), Jueyinshu (BL14) and Yishu (EX-B3) for Cardiac Autonomic Neuropathy in Patients With Type 2 Diabetes
The goal of this clinical trial is to learn whether acupuncture can improve damage to the nerves that control the heart (cardiac autonomic neuropathy) in adults with type 2 diabetes. It will also learn about the safety of this acupuncture treatment.
The main questions it aims to answer are:
Does acupuncture at three points on the back (Xinshu, Jueyinshu and Yishu), added to standard treatment, improve symptoms such as palpitations, chest tightness, fatigue and numbness? Does it improve test results that measure how well the heart's nerves work? Researchers will compare acupuncture plus mecobalamin (a form of vitamin B12) with mecobalamin alone to see whether adding acupuncture works better.
Participants will:
Continue their usual diabetes treatment and take mecobalamin tablets by mouth three times a day If assigned to the acupuncture group, receive acupuncture 3 times a week for 6 weeks, about 15 minutes each session Have blood tests, heart nerve function tests and symptom questionnaires at the start of the study and again at week 6
Inclusion: Aged 18 to 70 years; Diagnosed with type 2 diabetes according to the 1999 WHO diagnostic criteria; Cardiovascular autonomic neuropathy confirmed by cardiovascular autonomic reflex tests (CARTs).
Exclusion: Acute complications or severe chronic complications of diabetes; Acute cardiovascular disease, such as acute coronary syndrome, pulmonary embolism or ruptured aortic dissection; Acute infection, recent surgery, trauma or other stress states; Use of drugs that affect the heart, such as beta-blockers, atropine or digitalis, within the past 2 weeks; Severe heart, liver, lung or kidney insufficiency, or a history of malignancy; Diseases other than type 2 diabetes that may cause neuropathy, including: metabolic diseases (thyroid dysfunction, hypertriglyceridemia, amyloidosis); connective tissue diseases; inflammatory neurovascular diseases (Guillain-Barre syndrome, polyradiculopathy, cerebral infarction); psychiatric disorders (anxiety, depression, schizophrenia); nutritional deficiencies (vitamin B6, B12, E, etc.); alcohol dependence; exposure to neurotoxic agents (chemotherapy drugs, heavy metals, chemical products); and chronic infectious diseases (hepatitis B, syphilis, HIV infection); Unable to cooperate with testing because of cognitive impairment or intellectual factors; Primary cardiomyopathy, such as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular or unclassified cardiomyopathy; Use of alcohol, caffeine or sedatives within the past 24 hours.