Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis.
Key facts
- Where
- Lahore, PakistanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 65 years old?
Source: NCT07908589, who can take part
Where in Pakistan
- UMTLahore, PakistanContact: Fizza Masood Dr., MS-OMPTNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Management and Technology Lahore
- Trial code
- NCT07908589
- Record updated
- 2 November 2026
- Original description
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in patients with knee osteoarthritis. The study will recruit 32 participants aged 40-65 with Grade I-II knee osteoarthritis and randomly allocate them into two groups for a 6-week intervention at Ch Rehmat Ali Memorial Trust Hospital. Group A will perform strengthening exercises (such as sit-to-stand, mini squats, and leg raises) using a controlled 3-1-3 second tempo cadence (eccentric, isometric hold, concentric), while Group B will perform the same exercises at a self-selected speed; both groups will receive preparatory moist heat, warm-ups, knee isometrics, and Maitland mobilizations three times weekly. Primary outcomes-including pain intensity (NPRS), functional difficulty (WOMAC), walking endurance (6MWT), and mobility (TUG)-will be evaluated at baseline and 6 weeks to determine if tempo control offers a more effective, well-tolerated alternative for managing knee osteoarthritis.Read full original descriptionShow less
Effects of Tempo-Controlled Low-load Resistance Training on Pain, Muscle Performance and Disability in Patients With Knee Osteoarthritis.
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in patients with knee osteoarthritis. The study will recruit 32 participants aged 40-65 with Grade I-II knee osteoarthritis and randomly allocate them into two groups for a 6-week intervention at Ch Rehmat Ali Memorial Trust Hospital. Group A will perform strengthening exercises (such as sit-to-stand, mini squats, and leg raises) using a controlled 3-1-3 second tempo cadence (eccentric, isometric hold, concentric), while Group B will perform the same exercises at a self-selected speed; both groups will receive preparatory moist heat, warm-ups, knee isometrics, and Maitland mobilizations three times weekly. Primary outcomes-including pain intensity (NPRS), functional difficulty (WOMAC), walking endurance (6MWT), and mobility (TUG)-will be evaluated at baseline and 6 weeks to determine if tempo control offers a more effective, well-tolerated alternative for managing knee osteoarthritis.
Inclusion: Patients diagnosed with knee osteoarthritis according to clinical criteria. Age between 40-65 years. Both male and female participants. NPRS pain score between >3/10 and 6/10. Radiographic grade I-II knee osteoarthritis. Ability to walk independently without assistive device.
Exclusion: Recent knee surgery within the last six months. Inflammatory joint diseases such as rheumatoid arthritis. Severe diagnosed cardiovascular or neurological disorders. Intra-articular injections within previous three months. Uncontrolled hypertension or diabetes. Severe diagnosed knee deformities requiring surgical intervention. Cognitive impairment (Parkinson) affecting exercise participation.