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Comparing Two Blood Pressure Goals in People Having Peritoneal Dialysis

Compares two blood pressure goals in adults on peritoneal dialysis with high blood pressure.

Key facts

Who runs it
University of California, San Francisco
Where
San Francisco, United StatesSee the 3 sites
Trial code
Registry title
Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot Trial
Status
Recruiting
People taking part
10 people, planned
Started
30 Oct 2026
Expected to end
Jun 2027
Type of study
Interventional, 2 groups
Treatments tested
  • Target systolic blood pressure <120 mmHg.
  • Target systolic blood pressure <140 mmHg
Record updated
6 November 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with end-stage kidney disease and high blood pressure who have been on peritoneal dialysis for at least 4 months.

Age
18 years or older
Sex
All sexes can join.
Disease stage
End-stage kidney disease treated with regular peritoneal dialysis, with high blood pressure.
Earlier treatment
On peritoneal dialysis for at least 4 months. High blood pressure means taking blood pressure medicines or having clinic systolic blood pressure of 140 mmHg or higher over the month before screening.
Biomarker or test result
Blood pressure must be measurable on the upper arm (brachial).

Main reasons for not taking part

  • Planned transplant or move to haemodialysis within 4.5 months
  • Expected life span under 4.5 months
  • Taking part in another trial that may affect blood pressure care
  • Pregnant, planning pregnancy or breastfeeding
  • Living in prison or an institution that prevents home blood pressure measurement

This trial only enrols participants on dialysis. The registry sentence this rests on: Undergoing regular PD for treatment of ESKD.

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Age ≥ 18 years
  • Undergoing regular PD for treatment of ESKD
  • On PD for ≥ 4 months. (We do not plan to enroll patients within the first 3 months of PD initiation because there can be large fluctuations in volume status and BP readings before patient coming into more of a steady state. We then require participants to have at least 1 month of BP data to allow calculation of an average pre-enrollment BP for screening for study entry.)
  • Diagnosis of HTN defined as being on antihypertensive medications or having routine clinic SBP ≥ 140 mmHg averaged over prior one month to screening
  • Able to measure brachial BP

Who cannot take part

  • Planned transplant or HD transition < 4.5 months (the duration of study)
  • Pregnancy, anticipated pregnancy, or breastfeeding as this will limit the use of certain antihypertension medications in the study and pose additional risks to the patient and many pregnant patients are transitioned over to hemodialysis
  • Presence of a condition or abnormality that, in the opinion of the study team or treating nephrologist, would compromise the safety of the patient or the quality of the data
  • Estimated life expectancy < 4.5 months (also determined by asking the treating nephrologist)
  • Participation in another clinical trial that may affect BP management
  • Incarceration or institutionalized living which may prohibit measurement of home BP

Where in United States

  • Satellite Healthcare - Daly CitySan Francisco, United StatesContact: Kashvi Gupta, MD, MPHTaking people
  • Satellite Healthcare - San Francisco GearySan Francisco, United StatesContact: Kashvi Gupta, MD, MPHTaking people
  • Zuckerberg San Francisco General HospitalSan Francisco, United StatesContact: Kashvi Gupta, MD, MPHNot yet recruiting

About the trial

What the trial wants to find out

The GOAL-BP pilot study will help determine whether a study comparing two blood pressure goals can be carried out in adults with end-stage kidney disease and high blood pressure who receive peritoneal dialysis. The main questions it aims to answer are whether eligible patients can be recruited for the study.

Read full original descriptionShow less

Researchers will compare two goals for the top blood pressure number (systolic blood pressure): below 120 mmHg versus below 140 mmHg.This pilot study will help plan a larger trial in the future.

Participants will:

* Be assigned by chance to one of the two blood pressure goals. * Have their blood pressure measured at clinic visits about every two weeks. * Work with their kidney doctor on recommended changes to fluid management, peritoneal dialysis treatment, or blood pressure medicines to reach their assigned goal. * Be part of the study for about four and a half months.

The 2 groups in the trial

  • InterventionOther group

    Target systolic blood pressure \<120 mmHg

    Treatment: Target systolic blood pressure <120 mmHg.

  • ControlOther group

    Target systolic blood pressure \<140 mmHg

    Treatment: Target systolic blood pressure <140 mmHg

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot Trial
Plain-language title
Comparing Two Blood Pressure Goals in People Having Peritoneal DialysisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 13 November 2026.
Record updated
6 November 2026