Emotional distress and symptoms in advanced lung cancer, with and without brain metastasis
Follows distress and symptoms in adults with advanced lung cancer, comparing brain metastasis groups.
Plain-language title generated from the registry record
Registry title: ePRO in Advanced Lung Cancer: Emotional Distress, Symptom Burden, Brain Metastasis
Key facts
- Where
- Hubei, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with stage IV non-small cell or small cell lung cancer, with or without brain metastasis, who can fill in electronic questionnaires on a phone or tablet.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Stage IV non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC), confirmed by pathology and imaging. One group has no brain metastasis; the other group has brain metastasis.
- Earlier treatment
- Cannot have had any anti-tumor treatment before.
Main reasons for not taking part
- Prior anti-tumor treatment
- Severe chronic disease of the heart, liver, kidney or other vital organs
- Abnormal consciousness or mental status
- Cannot understand the study content and requirements
- Another cancer in the past
Read by machine on 9 November 2026.
Where in China
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHubei, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Qian Chu
- Trial code
- NCT07912190
- Record updated
- 3 November 2026
- Original description
This study intends to adopt a prospective longitudinal research design to comprehensively evaluate patient-reported emotional stress and symptom burden in patients with advanced lung cancer and lung cancer brain metastasis during first-line and maintenance treatment, extract symptom clusters, and describe the longitudinal dynamic trajectories of symptoms and symptom clusters over time. Meanwhile, it analyzes the relationships between brain metastasis and emotional stress as well as symptom trajectories.Read full original descriptionShow less
A Study on the Correlation of Emotional Distress and Symptom Burden With Brain Metastasis Status in Patients With Advanced Lung Cancer Based on Electronic Patient-reported Outcomes
This study intends to adopt a prospective longitudinal research design to comprehensively evaluate patient-reported emotional stress and symptom burden in patients with advanced lung cancer and lung cancer brain metastasis during first-line and maintenance treatment, extract symptom clusters, and describe the longitudinal dynamic trajectories of symptoms and symptom clusters over time. Meanwhile, it analyzes the relationships between brain metastasis and emotional stress as well as symptom trajectories.
Patients will be divided into three cohorts according to the status of brain metastasis: non-metastasis, stable brain metastasis, and progressive brain metastasis. Differences in emotional stress, symptom burden and symptom cluster manifestations among subgroups will be further compared, together with their correlations with brain metastasis. This study aims to improve the understanding of the characteristics of symptom burden and symptom cluster profiles mediated by emotional stress in lung cancer patients throughout treatment.
Inclusion: Non-brain metastasis cohort: patients with stage IV non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) confirmed by pathology and imaging, without brain metastasis; Brain metastasis cohort: patients with pathologically and radiologically confirmed stage IV NSCLC and SCLC accompanied by brain metastasis; Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2; Age ≥ 18 years old; Estimated survival time ≥ 3 months; Capable and willing to repeatedly complete electronic questionnaires via smartphones or tablets; All enrolled patients signed the hospital-approved informed consent form.
Exclusion: Prior receipt of anti-tumor treatment; Complicated with severe chronic diseases of the heart, liver, kidney and other vital organs; A previous medical history of other malignant tumors; Abnormal consciousness or mental status; Inability to understand the research content and requirements.