NCT07917416Not yet recruiting
Home-based Inspiratory Muscle Training in Pulmonary Hypertension
Efficacy of Inspiratory Muscle Training Delivered Through Telerehabilitation on Ventilatory Efficiency in People With Pulmonary Hypertension: a Double-blind, Placebo-controlled Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The main objective of this study is to determine whether an 8-week inspiratory muscle training (IMT) programme, delivered at home through telerehabilitation, improves ventilatory efficiency (VE/VCO2 slope) compared with a sham (placebo) training programme in adults with pulmonary hypertension. Secondary objectives are to analyse its effects on airway inflammation, inspiratory muscle strength, lung function, ventilatory pattern and mechanical efficiency during exercise, dyspnoea and health-related quality of life. Forty participants will be randomly allocated (1:1) to active IMT or sham IMT. Both groups will train twice a day, 5 days a week, for 8 weeks, with biweekly load adjustments and supervision through video calls. Participants, therapists, outcome assessors and the statistician will be blinded to group allocation.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 27 Oct 2026
- Start date
- Nov 2026
- Primary completion date
- Jan 2028
- Lead sponsor
- Universidad Complutense de Madrid
- NCT number
- NCT07917416
What you commit to
- Study type: Interventional
- Planned participants: 40
- From Nov 2026 to the primary completion date, Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Thoracic or abdominal surgery in the previous 3 months.
- Current participation in cardiopulmonary rehabilitation, or participation in the previous 3 months.
Other illness
- Neuromuscular disease or conditions with primary diaphragmatic involvement.
- Severe comorbidities unrelated to PH pathophysiology (e.g., severe COPD or unstable ischaemic heart disease).
Other
- Absolute contraindications to cardiopulmonary exercise testing according to current guidelines.
- Pregnancy or breastfeeding.
- Inability to understand or follow the telerehabilitation programme.
Who the study is looking for
- Age 18 years or older.
- Medical diagnosis of pulmonary hypertension group 1 (pulmonary arterial hypertension) or group 4 (chronic thromboembolic pulmonary hypertension) according to the 2022 ESC/ERS guidelines.
- Transthoracic echocardiography performed within the previous 6 months.
- Clinical stability: no hospitalizations, changes in PH-specific treatment or worsening of functional class in the previous 3 months.
- Sufficient functional capacity to perform cardiopulmonary exercise testing and the other study assessments.
- Signed informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidad Complutense de Madrid Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.