NCT07919353Not yet recruiting
Penn Family Screening for Familial Hypercholesterolemia (NHLBI R33) Trial 3
Leveraging Behavioral Economics to Implement Cascade Screening in Individuals With Familial Hypercholesterolemia
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test two implementation strategies (digital strategy vs. care navigator strategy) to promote family cascade screening for familial hypercholesterolemia (FH) in Penn Medicine patients diagnosed with FH ("probands"). The main questions this study aims to answer are: (1) evaluating the effect of the approaches on reach (proportion of probands who have at least one family member who completes screening), number of family members screened, proband engagement with the study, and proband LDL-C levels; and (2) use mixed methods to identify implementation strategy mechanisms. Participants (probands) will receive messaging that provides education about FH and provides instructions for participating in family cascade screening. A subset of participants will be invited to complete a qualitative interview about their experience receiving the implementation strategy. The research team will compare the arms to evaluate their effectiveness at promoting cascade screening.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 30 Oct 2026
- Start date
- 15 Nov 2026
- Primary completion date
- 28 Feb 2027
- Lead sponsor
- Northwestern University
- Diseases
- Familial hypercholesterolaemia
- NCT number
- NCT07919353
What you commit to
- Study type: Interventional
- Planned participants: 110
- From 15 Nov 2026 to the primary completion date, 28 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participated in a prior FH cascade screening study at Penn Medicine
Other
- Does not positively confirm identity
- Unreachable by mail, phone, text, and email (i.e., all messages undeliverable)
- Those who self-report not having contact information for at least 1 living biological first-degree relative in the US and/or report that all eligible relatives have already completed cascade screening
Who the study is looking for
- Current or recent Penn Medicine patient (i.e., had a visit with a Penn Medicine clinician in the past 2 years)
- Age 18 or older
- Clinically diagnosed FH
- At least one contact method available in the electronic health record
- Alive
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Perelman School of Medicine | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.