Two-stage liver surgery with partial transplant for liver-spread colon cancer
Tests a two-stage liver surgery in adults with colon cancer spread to the liver.
Plain-language title generated from the registry record
Registry title: RAPID for Unresectable Colorectal Liver Metastases
Key facts
- Where
- Guangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT07919951, who can take part
Where in China
- Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Trial code
- NCT07919951
- Record updated
- 5 November 2026
- Original description
The goal of this clinical trial is to learn if the RAPID procedure works to treat colorectal cancer that has spread to the liver and cannot be removed by surgery. It will also learn about the safety of the procedure. The main questions it aims to answer are:Read full original descriptionShow less
Efficacy of the RAPID Procedure (Resection and Partial Liver Transplantation With Delayed Total Hepatectomy) for Unresectable Colorectal Liver Metastases: A Prospective Clinical Study
The goal of this clinical trial is to learn if the RAPID procedure works to treat colorectal cancer that has spread to the liver and cannot be removed by surgery. It will also learn about the safety of the procedure. The main questions it aims to answer are:
1. How many participants are alive without the cancer progressing or returning 2 years after the first-stage surgery? 2. How many participants complete the second-stage surgery, and how quickly does the liver graft grow between the two stages? 3. What medical problems do participants have around the time of surgery, including serious complications?
Participants will:
1. Undergo the first-stage surgery: removal of the left part of the liver and implantation of a small liver graft, with the right portal vein tied off to help the graft grow; 2. Have blood tests and ultrasound checks after surgery, and regular CT or MRI scans to measure graft growth;
(4) Undergo the second-stage surgery to remove the remaining diseased liver once the graft has grown enough (5) Visit the clinic every 3 months for up to 2 years after the second-stage surgery for checkups, imaging, and blood tests to see if the cancer has returned
Inclusion: Age 18 to 65 years; ECOG performance status 0 to 1; Histologically confirmed colorectal adenocarcinoma; primary tumor radically resected, or resectable synchronously or in a staged manner; Unresectable colorectal liver metastases as assessed by a multidisciplinary team (hepatobiliary surgery, medical oncology, radiology); No unresectable extrahepatic metastases; Received standard chemotherapy plus targeted therapy, with stable disease; BRAF V600E wild-type and microsatellite stable (MSS); Child-Pugh class A, without clinically significant portal hypertension; Signed written informed consent and able to comply with the protocol and follow-up.
Exclusion: Primary colorectal tumor not amenable to radical resection; Prior solid organ transplantation; HIV infection; Severe hepatic insufficiency (Child-Pugh class B or C), or clinically significant portal hypertension; Severe cardiopulmonary or renal insufficiency, or judged by the surgeon to be unable to tolerate two-stage major surgery; Other malignancy diagnosed within the past 5 years (except cured basal cell carcinoma of the skin or carcinoma in situ of the cervix); Unresectable extrahepatic metastases (resectable pulmonary nodules are permitted); BRAF V600E mutation or microsatellite instability-high (MSI-H); Pregnant or breastfeeding women, or women planning pregnancy during the study.