Affective Cognitive Training in Mood Disorders and High-risk Relatives
Key facts
- Where
- Frederiksberg, DenmarkSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07920302, who can take part
Where in Denmark
- Neurocognition and Emotion Across Disorders Brain Centre (NEAD)Frederiksberg, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
- Trial code
- NCT07920302
- Record updated
- 5 November 2026
- Original description
The aim of this clinical trial is to investigate the effects of a six-week targeted affective cognitive training, combining virtual reality and computer-based exercises, in symptomatically stable patients with mood disorders (major depressive disorder or bipolar disorder) and unaffected first-degree relatives.Read full original descriptionShow less
Brain Marker for Affective Cognitive Enhancement Following Targeted Training in Patients With Mood Disorders and High-risk Relatives: A Randomized Controlled Trial (BACE)
The aim of this clinical trial is to investigate the effects of a six-week targeted affective cognitive training, combining virtual reality and computer-based exercises, in symptomatically stable patients with mood disorders (major depressive disorder or bipolar disorder) and unaffected first-degree relatives.
The investigators hypothesize that targeted affective cognitive training, compared with treatment as usual, will improve affective cognition (primary outcome), assessed using a composite measure of emotion regulation and facial emotion recognition.
Secondly, the investigators hypothesize that the training will improve self-reported emotion regulation abilities and associated neural activity during emotion regulation, including changes in dorsolateral prefrontal cortex activity.
Finally, the investigators will explore whether the training affects broader cognitive functioning, psychosocial functioning, quality of life, and longer-term clinical outcomes, including relapse or onset of mood disorder.
Inclusion: Confirmed ICD-10 diagnosis of BD or previous UD in partial, or full remission (Hamilton Depression Rating Scale-17 items and Young Mania Rating Scale scores ≤14); Self-reported difficulties with emotion regulation (measured with Difficulties in Emotion Regulation Scale DERS: total score or at least two subscores ≥ 1 SD above expected norms); Fluency in Danish language.
Exclusion: Previous severe head trauma; Pacemaker or other metal implants; Received electroconvulsive therapy < 3 months prior to participation; Autism spectrum disorder; Neurological disorder; Diagnosis of schizophrenia; Alcohol or substance abuse; Pregnancy; Claustrophobia; Daily use of benzodiazepines > 22.5 mg. oxazepam or > 7.5 mg. diazepam per day.