Nutritional Intervention After Total Gastrectomy for Gastric Cancer
Key facts
- Where
- Hanoi, VietnamSee the site
Where in Vietnam
- Hanoi Medical UniversityHanoi, VietnamNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hanoi Medical University
- Trial code
- NCT07920705
- Record updated
- 9 November 2026
- Original description
This prospective, 1:1 group-matched non-randomized controlled trial evaluates the impact of a structured perioperative nutritional intervention on functional gastrointestinal recovery, post-operative length of hospital stay, anthropometries status, paraclinical test, and multidimensional nutritional-immunological status in gastric cancer patients undergoing elective radical total gastrectomy.Read full original descriptionShow less
Effectiveness Of Nutritional Intervention In Patients Undergoing Total Gastrectomy For Gastric Cancer at Vietnam National Cancer Hospital
This prospective, 1:1 group-matched non-randomized controlled trial evaluates the impact of a structured perioperative nutritional intervention on functional gastrointestinal recovery, post-operative length of hospital stay, anthropometries status, paraclinical test, and multidimensional nutritional-immunological status in gastric cancer patients undergoing elective radical total gastrectomy.
Total gastrectomy induces severe surgical stress, catabolic malnutrition, and rapid loss of body weight and muscle mass, which severely compromises post-operative immune function and clinical recovery. Standard perioperative care often lacks structured, post-discharge immunonutrient supplementation, leaving patients at high risk for prolonged catabolic depletion.
In this study, eligible post-total gastrectomy gastric cancer patients were allocated via 1:1 group matching based on age, sex, AJCC tumor stage, and baseline malnutrition status (GLIM criteria) into two arms (n = 38 per arm):
1. Nutritional Intervention Group: Received structured perioperative care along with individualized dietary counseling and daily oral nutritional supplementation (ONS; Orgalife 500 mL/day providing 600 kcal, 33 g protein, arginine, glutamine, and omega-3 fatty acids) for 30 consecutive days post-surgery. 2. Standard Care Control Group: Received standard perioperative surgical care and routine post-gastrectomy dietary advice without structured ONS supplementation.
Primary outcome measures include gastrointestinal recovery metrics (time to first flatus and time to oral feeding initiation) and postoperative length of hospital stay. Secondary outcomes comprise multidimensional nutritional-immunological assessments at baseline (T0) and 1 month postoperatively (T1), evaluated by GLIM criteria, Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT) score, body composition, serum albumin, protein levels, anemia, and 30-day postoperative complication rates.
Inclusion: Age ≥ 20 years (both male and female); Histologically confirmed diagnosis of gastric adenocarcinoma; Scheduled to undergo elective radical total gastrectomy for gastric cancer at National Cancer Hospital (K Hospital); Complete medical records and baseline clinical data available; Provided written informed consent to participate in the study protocol.
Exclusion: Undergoing emergency total gastrectomy or non-elective surgical intervention; Presence of severe concomitant systemic end-organ dysfunction (e.g., severe hepatic failure, renal failure, decompensated heart failure, or acute pancreatitis); Undergoing combined multi-organ resections outside standard gastric cancer surgery protocols; Severe cognitive impairment, psychiatric disorder, or communication barrier hindering informed consent or dietary compliance; Known history of severe allergy or lactose intolerance to ingredients contained in the oral nutritional supplement (dairy/soy protein formulas); Pregnant or lactating women.