Additional Effects on tDCS With AOT on Lower Limb Functions on Children With Diplegic CP
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 5 and 15 years old?
Source: NCT07921095, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
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- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Riphah International University
- Trial code
- NCT07921095
- Record updated
- 6 November 2026
- Original description
The goal of this clinical trial is to evaluate the therapeutic effects of combining active transcranial direct current stimulation (tDCS) with Action Observation Therapy (AOT) in pediatric patients diagnosed with spastic Cerebral Palsy. The main questions it aims to answer are:Read full original descriptionShow less
Additional Effects on Transcranial Direct Current Stimulation (tDCS) With Action Observation Therapy on Lower Limb Functions on Children With Diplegic Cerebral Palsy
The goal of this clinical trial is to evaluate the therapeutic effects of combining active transcranial direct current stimulation (tDCS) with Action Observation Therapy (AOT) in pediatric patients diagnosed with spastic Cerebral Palsy. The main questions it aims to answer are:
1. Does combining tDCS with AOT yield significantly greater improvements in gross motor function (measured by GMFM-88) compared to AOT alone? 2. Does active tDCS paired with AOT lead to greater reductions in spasticity (MAS) and improvements in walking speed (10MWT) at 6 weeks post-intervention?
Researchers will compare participants receiving active tDCS plus AOT against a control group receiving sham tDCS plus AOT to isolate the synergistic effects of active brain stimulation.
Participants will:
1. Complete baseline clinical evaluations including gross motor, spasticity, and gait assessments. 2. Undergo scheduled intervention sessions consisting of tDCS administration combined with video-based Action Observation Therapy. 3. Attend follow-up assessment sessions at the end of the intervention period and 6 weeks post-intervention.
Inclusion: Participants diagnosed with spastic diplegic cerebral palsy with a Modified Ashworth Scale (MAS) score of 2; Age between 6 to 12 years old; Participants classified as Communication Function Classification System (CFCS) Level II; Participant with CFCS Level II.
Exclusion: Implanted metallic or electronic devices (e.g., pacemaker, cochlear implant, deep brain stimulator); Orthopedic surgery to the affected limb(s) within the past 12 months or planned during study period; Current use of medications significantly affecting cortical excitability (e.g., high-dose benzodiazepines, anticonvulsants), unless cleared by neurologist; Presence of uncontrolled epilepsy (any seizure within the past 6 months); Severe visual impairment (not correctable with aids) preventing participation in action observation tasks; Skin conditions, lesions, or infections at electrode placement sites; Any medical or psychiatric condition that, in the investigator's judgment, makes participation unsafe or interferes with study outcomes; Severe dystonia, ataxia, or predominant weakness interfering with upper limb or lower limb function; Botulinum toxin injections in the affected limb(s) within the past 6 months or planned during study period; Participation in another interventional clinical trial within the past 3 months.