Measuring body responses to vagus nerve stimulation in stroke recovery
Tests vagus nerve stimulation with arm exercise in adults with lasting stroke weakness.
Plain-language title generated from the registry record
Registry title: Biomarkers of Paired VNS
Key facts
- Where
- Boston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07922200, who can take part
Where in United States
- MGH Institute of Health ProfessionsBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- MGH Institute of Health Professions
- Trial code
- NCT07922200
- Record updated
- 6 November 2026
- Original description
Paired Vagus Nerve Stimulation (VNS) has been shown to enhance upper extremity motor recovery after ischemic stroke. Prior studies have focused primarily on long-term clinical outcomes, leaving the short-term physiologic response to the intervention poorly understood. The purpose of this study is to examine real-time responses to Vagus Nerve Stimulation (VNS) in individuals with chronic motor impairments after ischemic stroke to better inform Paired VNS dosing. We plan to enroll 50 participants into a single-arm study and perform neurophysiologic assessments during VNS to identify objective markers of stimulation response and examine dose-response relationships.Read full original descriptionShow less
Biomarkers of Paired Vagus Nerve Stimulation Therapy for Stroke Motor Rehabilitation
Paired Vagus Nerve Stimulation (VNS) has been shown to enhance upper extremity motor recovery after ischemic stroke. Prior studies have focused primarily on long-term clinical outcomes, leaving the short-term physiologic response to the intervention poorly understood. The purpose of this study is to examine real-time responses to Vagus Nerve Stimulation (VNS) in individuals with chronic motor impairments after ischemic stroke to better inform Paired VNS dosing. We plan to enroll 50 participants into a single-arm study and perform neurophysiologic assessments during VNS to identify objective markers of stimulation response and examine dose-response relationships.
Inclusion: Age ≥ 18 years old and ≤ 80 years old; Implanted with VNS device for post-stroke motor rehabilitation; Ability to follow simple commands in English.
Exclusion: Prior history of developmental, neurologic, or major psychiatric disorder resulting in functional disability; Visual or auditory disorders limiting ability to participate in study procedures; Evidence of an uncontrolled seizure disorder; Patients for whom EEG leads are contraindicated; Pregnancy.