Testing temporally interfering electrical brain stimulation for major depressive disorder
Tests electrical brain stimulation in adults with major depressive disorder.
Plain-language title generated from the registry record
Registry title: Individualized Temporally Interfering Electrical Stimulation in Major Depressive Disorder
Key facts
- Where
- Fuzhou and Tianjin, ChinaSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07924917, who can take part
Where in China
- Fuzhou Neuropsychiatric Hospital Affiliated to Fujian Medical UniversityFuzhou, ChinaTaking people
- Tianjin Anding HospitalTianjin, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Tianjin Medical University General Hospital
- Trial code
- NCT07924917
- Record updated
- 9 November 2026
- Original description
Temporally interfering (TI) electrical stimulation is a novel noninvasive neuromodulation technique with high spatial resolution. Although its effects on human brain function and behavior have been increasingly investigated, its clinical utility in major depressive disorder (MDD) has not been established. This trial aims to evaluate the efficacy and safety of TI electrical stimulation in MDD patients.Read full original descriptionShow less
Closed-Loop Bio-Machine Interaction System and Applications in Psychiatric Diagnosis and Treatment
Temporally interfering (TI) electrical stimulation is a novel noninvasive neuromodulation technique with high spatial resolution. Although its effects on human brain function and behavior have been increasingly investigated, its clinical utility in major depressive disorder (MDD) has not been established. This trial aims to evaluate the efficacy and safety of TI electrical stimulation in MDD patients.
Inclusion: Meets Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for MDD, confirmed independently by two psychiatrists; Currently experiencing a depressive episode; Hamilton Depression Rating Scale 17-item (HAMD-17) score ≥ 17; Aged between 18-65 years; No restrictions on sex or gender; Attained at least junior high school education; lower education permitted if cognitive capacity is confirmed by a physician; Normal or corrected-to-normal vision and normal hearing; No use of antidepressant within two weeks prior to enrollment, or ongoing antidepressant treatment judged by a psychiatrist to be in a stable treatment phase; Ability to read and understand informed consent and self-report assessment scales; Willingness to participate in the study, with written informed consent provided by the participant or a legal guardian.
Exclusion: Receipt of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or other neuromodulation therapies within the past six months; History of any psychiatric disorder other than MDD; History of traumatic brain injury or coma; History of organic brain disease or severe systemic medical illness; History of cochlear implants, pacemakers, or other implanted brain devices; History of epileptic seizures or family history of epilepsy; History of alcohol use disorder or use of other psychoactive substances; Any condition precluding informed consent or compliance with study procedures; Obvious suicidal or impulsive violent behavior; Participation in other interventional clinical trials.