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Comparison Between Different Insulin Resistance Markers and Their Correlation With Severity of Coronary Artery Disease in Non-diabetic Patients.

Key facts

Where
Sohag, EgyptSee the site

Where in Egypt

  • Sohag University HospitalSohag, EgyptNo longer taking part

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Trial details

Who runs it
Sohag University
Trial code
NCT07928336
Record updated
10 November 2026
Original description
This study aims to investigate the association between insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. Furthermore, it evaluates the predictive value of multiple insulin resistance indices - specifically, the homeostatic model assessment for insulin resistance (HOMA-IR), Metabolic score for insulin resistance (METS-IR), Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and triglyceride and glucose (TyG) index, as non-invasive markers of coronary artery disease severity. The diagnostic performance of these indices will be compared among patients with suspected CAD undergoing coronary angiography at the cardiac catheterization unit at Sohag University Hospital.Read full original descriptionShow less

This study aims to investigate the association between insulin resistance (IR) and coronary artery disease (CAD) in non-diabetic patients. Furthermore, it evaluates the predictive value of multiple insulin resistance indices - specifically, the homeostatic model assessment for insulin resistance (HOMA-IR), Metabolic score for insulin resistance (METS-IR), Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and triglyceride and glucose (TyG) index, as non-invasive markers of coronary artery disease severity. The diagnostic performance of these indices will be compared among patients with suspected CAD undergoing coronary angiography at the cardiac catheterization unit at Sohag University Hospital.

Inclusion: Aged ≥18 year; Both sexes; Non-diabetic patients based on glycosylated hemoglobin (HbA1c) ; Patient with Ischemic heart disease indicated for coronary angiography.

Exclusion: Insulin dependent diabetes; End-stage renal disease on dialysis; Patients age less than 18 years old; Pregnant women.

ClinicalTrials.gov NCT07928336