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Effects of Adjunctive Melatonin Gel in Type II Diabetics With Stage III-IV Periodontitis

Key facts

Where
New Cairo, EgyptSee the site

Where in Egypt

  • Badr University in CairoNew Cairo, EgyptNo longer taking part

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Trial details

Who runs it
Badr University
Trial code
NCT07928752
Record updated
10 November 2026
Original description
The goal of this clinical trial is to learn if melatonin gel works to treat deep periodontal pockets in diabetic patients with periodontisits.Read full original descriptionShow less

Effects of Adjunctive Melatonin Gel With Minimally Invasive Non-Surgical Therapy on Clinical Outcomes, Inflammatory Biomarkers and Glycemic Control in Type II Diabetics With Stage III-IV Periodontitis: A Randomized Controlled Clinical Trial

The goal of this clinical trial is to learn if melatonin gel works to treat deep periodontal pockets in diabetic patients with periodontisits.

The main question it aims to answer is:

Does melatonin gel when used with minimal invasive non surgical periodontal therapy show better healing effects.

Inclusion: Male and female participants. Patients diagnosed with Stage III / IV periodontitis. Presence of at least one site with probing pocket depth (PPD) ≥ 5 mm and clinical attachment loss consistent with Stage III/ IV periodontitis; Subjects with glycated hemoglobin higher than 6.5% were defined as diabetic.

Exclusion: Smokers: current or former, as smoking impairs periodontal healing capacity and response to periodontal treatments; Pregnancy and lactation due to ethical considerations and potential hormonal influences on periodontal tissues; Patient who received periodontal therapy within the previous 6 months. Use of antibiotics, anti-inflammatory drugs, or antioxidant supplement within the previous 6 months; Patient with systemic condition other than type 2 diabetes or medication that may affect periodontal healing.

ClinicalTrials.gov NCT07928752