Intra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint Osteoarthritis
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- How often do I need to come in, and for how long each time?
- Are travel costs paid?
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Contact the study team: see the registry record → Contacts and Locations
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- Who runs it
- Cairo University
- Trial code
- NCT07929103
- Record updated
- 10 November 2026
- Original description
The goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free mouth opening and remove TMJ sounds? Researchers will compare Vitamin D3 to a normal saline placebo group to see if intra-articular Vitamin D3 provides therapeutic benefits. Participants will:Undergo a diagnostic evaluation including a questionnaire, clinical examination, and MRI. Receive a single intra-articular injection of either 1 ml of Vitamin D3 (Cholecalciferol 200,000 IU) or 1 ml of normal saline into the superior joint compartment. Attend follow-up visits at two weeks, three months, and six months to assess pain scores, mouth opening, and presence of tmj sound.Read full original descriptionShow less
Efficacy of Intra-Articular Vitamin D3 Injection for Treatment of Temporomandibular Joint Osteoarthritis: A Randomized Clinical Trial
The goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free mouth opening and remove TMJ sounds? Researchers will compare Vitamin D3 to a normal saline placebo group to see if intra-articular Vitamin D3 provides therapeutic benefits. Participants will:Undergo a diagnostic evaluation including a questionnaire, clinical examination, and MRI. Receive a single intra-articular injection of either 1 ml of Vitamin D3 (Cholecalciferol 200,000 IU) or 1 ml of normal saline into the superior joint compartment. Attend follow-up visits at two weeks, three months, and six months to assess pain scores, mouth opening, and presence of tmj sound.
Inclusion: Patient with temporomandibular joint osteoarthritis according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), Axis I, Group III.b ; Age ≥18.
Exclusion: Previous TMJ surgery; Specific osteoarthritis like rheumatoid arthritis or psoriatric arthritis; Pregnant women or breastfeeding ones.