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Intra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint Osteoarthritis

Key facts

Where
Cairo, EgyptSee the site

Where in Egypt

  • Faculty of oral and dental Medicine - cairo universityCairo, EgyptNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Trial details

Who runs it
Cairo University
Trial code
NCT07929103
Record updated
10 November 2026
Original description
The goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free mouth opening and remove TMJ sounds? Researchers will compare Vitamin D3 to a normal saline placebo group to see if intra-articular Vitamin D3 provides therapeutic benefits. Participants will:Undergo a diagnostic evaluation including a questionnaire, clinical examination, and MRI. Receive a single intra-articular injection of either 1 ml of Vitamin D3 (Cholecalciferol 200,000 IU) or 1 ml of normal saline into the superior joint compartment. Attend follow-up visits at two weeks, three months, and six months to assess pain scores, mouth opening, and presence of tmj sound.Read full original descriptionShow less

Efficacy of Intra-Articular Vitamin D3 Injection for Treatment of Temporomandibular Joint Osteoarthritis: A Randomized Clinical Trial

The goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free mouth opening and remove TMJ sounds? Researchers will compare Vitamin D3 to a normal saline placebo group to see if intra-articular Vitamin D3 provides therapeutic benefits. Participants will:Undergo a diagnostic evaluation including a questionnaire, clinical examination, and MRI. Receive a single intra-articular injection of either 1 ml of Vitamin D3 (Cholecalciferol 200,000 IU) or 1 ml of normal saline into the superior joint compartment. Attend follow-up visits at two weeks, three months, and six months to assess pain scores, mouth opening, and presence of tmj sound.

Inclusion: Patient with temporomandibular joint osteoarthritis according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), Axis I, Group III.b ; Age ≥18.

Exclusion: Previous TMJ surgery; Specific osteoarthritis like rheumatoid arthritis or psoriatric arthritis; Pregnant women or breastfeeding ones.

ClinicalTrials.gov NCT07929103