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Carotid Ultrasound-based Assessment of Maternal Hemodynamics to Guide HYpertension Treatment in PREgnancy - Pilot Study

Key facts

Who runs it
Assistance Publique - Hôpitaux de Paris
Where
France4 sites in 1 countryChoose a country to see its sites
Trial code
Status
Not yet recruiting
People taking part
200 people, planned
Started
1 Nov 2026
Expected to end
1 Dec 2027
Type of study
Interventional
Treatments tested
  • Assessment of maternal hemodynamics
Record updated
12 November 2026

Who can take part

Age
18 years and older
Sex
Women only
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • Pregnant women > 18 years of age
  • Singleton pregnancy
  • 10th to 40th week of pregnancy
  • Patients affiliated with social security or an equivalent scheme
  • Signed informed consent

Who cannot take part

  • Known allergies to ultrasound gel
  • Multifoetal pregnancy
  • Patient on AME (state medical aid)
  • Patient under a legal protection measure: guardianship, curatorship, or judicial safeguard

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Carotid ultrasound-based assessment of maternal hemodynamics to guide HYpertension treatment in PREgnancy - Pilot study - CHYPRE-pilot Healthy pregnancy is associated with significant physiological hemodynamic changes that are critical for maternal adaptation and health. Insufficient adaptive changes can lead to pregnancy disorders such as preeclampsia. Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and foetal morbidity and mortality. Assessment of maternal hemodynamic alterations can improve management strategies by better risk stratification of pregnant women. Current methods for maternal hemodynamic measurement involve transthoracic echocardiography, requiring expert consultation with a cardiologist and highly trained staff. Simpler techniques like carotid ultrasound based hemodynamic assessment can potentially provide an easy-to perform alternative, requiring minimal training.

The group in the trial

  • Pregnant women (>18 years of age) between 10-40th week of pregnancyOther group

    We will recruit pregnant women (\>18 years of age) between 10-40th week of pregnancy. The study design will be cross-sectional with a total recruitment 200 pregnant women, during routine clinical visits.The element under investigation in this study is the use of carotid ultrasound-derived hemodynamic measurements as a surrogate for CO and PVR assessed by transthoracic echocardiography (TTE) in pregnant women.

    Treatment: Assessment of maternal hemodynamics

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Record updated
12 November 2026