Not yet taking people in United StatesNo phase
Tailored Education for Aging and Cognitive Health: A Health Behavior Change Intervention for Midlife Adults at Risk for Alzheimer's Disease and Related Dementias
Key facts
- Who runs it
- Rhode Island Hospital
- Where
- Providence, United StatesSee the site
- Trial code
- Status
- Not yet recruiting
- People taking part
- 280 people, planned
- Starts
- 15 Feb 2027
- Expected to end
- 30 Sept 2031
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- TEACH
- Basic health education
- Record updated
- 12 November 2026
Who can take part
- Age
- 40 years to 69 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Age 40-69 years
- Normal cognition (Telephone Interview for Cognitive Status-Modified > 32)
- English language fluency
- Participants must have at least two of six dementia risk factors:; BMI in the overweight or obesity range ( >24.9); Systolic blood pressure in the "elevated" range or higher (>120 mmHg); LDL cholesterol outside the "optimal" range (>100 mg/dL); HbA1C in the prediabetes or diabetes range (> 5.6%); APOE e4 allele; First-degree relative with ADRD
- Participants must have suboptimal engagement in at least one core health behavior:; Diet: Mediterranean Diet Adherence Screener (MEDAS) total score < 10; Physical activity: <120 minutes of moderate-intensity or <60 minutes of vigorous-intensity physical activity per week; Sleep: <=7 hours of sleep per night (past-week average)
Who cannot take part
- Prior diagnosis of Mild or Major Neurocognitive Disorder
- History of serious mental illness (i.e., schizophrenia, bipolar disorder)
- History of neurodevelopmental disorder (e.g., intellectual disability)
- Severe physical disability or unstable medical conditions that prevent safe engagement in recommended study activities (e.g., physical activity)
- Current alcohol or substance use disorder based on self-report
- Current Beck Depression Inventory score > 28
- Current enrollment in an ADRD prevention clinical trial
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 69 years old?
Where in United States
- Rhode Island HospitalProvidence, United StatesContact: Laura Korthauer, Ph.D.No longer taking part
About the trial
What the trial wants to find out
This Stage II behavioral intervention development project will examine the efficacy of a multi-domain health behavior intervention for primary prevention of Alzheimer's disease and related dementias (ADRD) in middle age.
The 2 groups in the trial
- ExperimentalTreatment being tested
TEACH Intervention
Treatment: TEACH
- ControlExisting treatment, for comparison
Basic Health Education
Treatment: Basic health education
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Testing the Efficacy of a Personalized Multi-Domain Behavioral Intervention for Alzheimer's Disease and Related Dementias Risk Reduction in Midlife
- Fit questions
- Built from NCT07933367, who can take part
- Record updated
- 12 November 2026