Early access
Sign in
Taking peopleNo phase

Bone Deterioration After Kidney Transplantation Assessed by DXA and HR-pQCT

Key facts

Who runs it
Medical University Innsbruck
Where
Austria1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
100 people, planned
Started
21 Oct 2026
Expected to end
31 Dec 2029
Type of study
Observational
Treatments tested
  • DXA and HR-pQCT
  • Blood and urine sampling
Record updated
13 November 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Age 18 years or older at the time of kidney transplantation
  • First kidney transplantation (living or deceased donor)
  • Ability and willingness to provide written informed consent
  • Enrolment possible within 10 days after kidney transplantation
  • Clinical stability sufficient to undergo imaging procedures

Who cannot take part

  • Previous kidney transplantation
  • Prior or ongoing treatment with antiresorptive or osteoanabolic therapies (e.g. bisphosphonates, denosumab, teriparatide) at the time of transplantation
  • Conditions precluding reliable bone imaging, including metal implants at the measurement sites
  • Known metabolic bone diseases unrelated to chronic kidney disease-mineral and bone disorder (CKD-MBD)
  • Any condition that, in the opinion of the investigator, would interfere with study participation, data quality or protocol adherence
  • Contraindications to HR-pQCT or DXA
  • Inability to undergo imaging due to physical or technical limitations

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The goal of this observational study is to learn how bone health changes during the first year after kidney transplantation in adults receiving their first kidney transplant.

Read full original descriptionShow less

The main questions it aims to answer are:

* How many patients show a clinically relevant decline in bone density or bone structure within 12 months after transplantation? * Does a standard bone density scan (DXA) detect these changes as well as a high-resolution scan of bone structure (HR-pQCT)?

Participants will:

* Have a DXA scan of the lower spine, hip and forearm and an HR-pQCT scan of the forearm and lower leg shortly after transplantation and again after 12 months. Participants followed up in Innsbruck may also have these scans after 6 months. * Give blood and urine samples at the same visits, taken together with routine blood tests whenever possible, for bone and mineral markers and storage in a biobank.

The study does not change any treatment. All treatment decisions remain with the patients' physicians.

The group in the trial

  • Kidney transplant recipients

    Adults (18 years or older) who received a first kidney transplant (living or deceased donor) at the Medical University of Innsbruck and are enrolled within 10 days after transplantation.

    Treatment: DXA and HR-pQCT and Blood and urine sampling

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prospective Imaging-based Assessment of Skeletal Deterioration After Kidney Transplantation Using DXA and HR-pQCT (DXACT Study)
Record updated
13 November 2026