Acute lymphoblastic leukaemia: open trials in Czechia

• NCT06395103

  Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

  Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC

  Fakultni Nemocnice Brno, Brno-Sever · Fakultni Nemocnice Motol a Homolka, Prague

  Registry updated 2026-10-30

• NCT07476729

  International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 (IntReALL BCP 2020)

  Trial Treatment · Phase 3 · Charite University, Berlin, Germany

  Fakultni nemocnice Brno, Brno · University Hospital Olomouc, Olomouc · Fakultni Nemocnice Plzen, Plzen 23 · Fakultni nemocnice v Motole, Prague

  Registry updated 2026-10-26

• NCT07297914

  Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL

  Trial Treatment · Phase 2/3 · Bambino Gesù Hospital and Research Institute

  University Hospital Motol, Prague

  Registry updated 2026-10-20

• NCT05327894

  Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia

  Trial Treatment · Phase 3 · Princess Maxima Center for Pediatric Oncology

  Fakultni Nemocnice Brno, Brno-Sever · University Hospital Olomouc, Olomouc · Fakultni Nemocnice V Motole, Prague 5

  Registry updated 2026-10-19

• NCT07648264

  Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies

  Trial Treatment · Phase 3 · CSL Behring

  FH Hradec Kralove, Hradec Králové · FH Ostrova, Ostrova · Fakultni nemocnice Kralovske Vinohrady, Prague · UHKT Praha, Prague

  Registry updated 2026-10-14

• 2025-522019-40-00

  Study of the safety and efficacy of asciminib in pediatric and young adult participants with r/r Ph+ or ABL-class Ph-like ALL

  Trial Treatment · Phase 1/2 · Novartis Pharma AG

  Institute of Hematology and Blood Transfusion, Prague · Fakultni Nemocnice Motol a Homolka, Prague

  Registry updated 2026-10-06

• NCT05748171

  A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL

  Trial Treatment · Phase 2 · Pfizer

  Fakultni Nemocnice Brno, Brno-Sever · Fakultni nemocnice v Motole, Prague

  Registry updated 2026-09-24

• NCT01949129

  Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

  Trial Treatment · Phase 2/3 · St. Anna Kinderkrebsforschung

  Fakultni nemocnice v Motole, Prague

  Registry updated 2026-09-04

• NCT04877522

  Asciminib Roll-over Study

  Trial Treatment · Phase 4 · Novartis Pharmaceuticals

  Fakultni nemocnice Brno, Brno · Fakultni Nemocnice Plzen, Plzen 23 · Fakultni Nemocnice Ostrava, Poruba · Institute of Hematology and Blood Transfusion, Prague · Fakultni nemocnice Kralovske Vinohrady, Prague

  Registry updated 2026-07-06

• 2024-516570-30-00

  A PRECISION MEDICINE RANDOMIZED TRIAL FOR PATIENTS WITH RELAPSED OR REFRACTORY T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA BASED ON A FUNCTIONAL APPROACH. ALL-TARGET TRIAL

  Trial Treatment · Phase 2 · Centre Hospitalier De Versailles

  Fakultni nemocnice Brno, Brno · Institute of Hematology and Blood Transfusion, Prague

  Registry updated 2026-06-08

• 2023-504694-20-00

  Inotuzumab ozogamicin for Acute Lymphoblastic Leukemia

  Trial Treatment · Phase 1/2 · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

  Fakultni Nemocnice V Motole, Prague 5

  Registry updated 2026-06-04

• 2025-520982-39-00

  Study on chemotherapy and experimental drugs in patients with Philadelphia Chromosome positive and ABL-class Philadelphia Chromosome-Like B-cell Acute Lymphoblastic Leukemia

  Trial Treatment · Phase 3 · Universita Degli Studi Di Milano Bicocca

  Fakultni nemocnice Brno, Brno · University Hospital Olomouc, Olomouc · Fakultni nemocnice v Motole, Prague

  Registry updated 2026-05-08

• NCT06051409

  A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)

  Trial Treatment · Phase 3 · Ascentage Pharma Group Inc.

  Fakultni nemocnice Brno, Brno · Fakultni nemocnice Hradec Kralove, Hradec Králové · Fakultni nemocnice Ostrava, Ostrava · Institute of Hematology and Blood Transfusion, Prague · Fakultni nemocnice Kralovske Vinohrady, Prague

  Registry updated 2026-04-30

• NCT03590171

  International Study for Treatment of High Risk Childhood Relapsed ALL 2010

  Trial Treatment · Phase 2 · Charite University, Berlin, Germany

  Fakultni nemocnice Brno, Brno · Fakultni nemocnice v Motole, Prague

  Registry updated 2026-03-17

• NCT03643276

  Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

  Trial Treatment · Phase 3 · Martin Schrappe

  Fakultni Nemocnice Brno, Brno-Sever · Nemocnice České Budějovice, a.s., České Budějovice · Fakultni Nemocnice Hradec Kralove, Novy Hradec Kralove · University Hospital Olomouc, Olomouc · Fakultni nemocnice Ostrava, Ostrava · Fakultni Nemocnice Plzen, Plzen 23 · Fakultni nemocnice v Motole, Prague · Krajska zdravotni a.s., Usti Nad Labem

  Registry updated 2025-04-06

• NCT05054257

  CART19 Cells Effects in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma

  Trial Treatment · Phase 1 · Institute of Hematology and Blood Transfusion, Czech Republic

  Institute of Hematology and Blood Transfusion, Prague

  Registry updated 2025-01-06

All Acute lymphoblastic leukaemia trials and the map

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