Acute lymphoblastic leukaemia: open trials in United Kingdom

• NCT06395103

  Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

  Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC

  Birmingham Children's Hospital-Oncology/Haematology (Site 1349), Birmingham · University Hospital of Wales (Site 1346), Cardiff · University College London Hospital (Site 1350), London · Royal Victoria Infirmary-Great North Children's Hospital (Site 1348), Newcastle upon Tyne · Royal Marsden Hospital (Sutton)-Drug Development Unit (Site 1347), Sutton

  Registry updated 2026-10-30

• NCT07155226

  Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

  Trial Treatment · Phase 1/2 · AstraZeneca

  Edinburgh · London · Manchester · Newcastle

  Registry updated 2026-10-23

• NCT07109219

  Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia

  Trial Treatment · Phase 1/2 · AstraZeneca

  Bloomsbury · Manchester

  Registry updated 2026-10-15

• NCT07648264

  Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies

  Trial Treatment · Phase 3 · CSL Behring

  Leicester Royal Infirmary, Leicester · Hammersmith Hospital, London · St. Bartholomew's Hospital, London

  Registry updated 2026-10-14

• NCT06137118

  AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia

  Trial Treatment · Phase 1/2 · AstraZeneca

  London · Manchester · Surrey

  Registry updated 2026-10-13

• NCT03934372

  Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors

  Trial Treatment · Phase 1/2 · Incyte Biosciences International Sàrl

  Royal Hospital For Sick Children Yorkhill Glasgow, Glasgow · Alder Hey Childrens Nhs Foundation Trust, Liverpool · The Royal Marsden NHS Foundation Trust - Sutton, Sutton

  Registry updated 2026-10-09

• NCT06173518

  A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

  Trial Treatment · Phase 1 · Autolus Limited

  Great Ormond Street Hospital For Children NHS Foundation Trust, London · Royal Manchester Children's Hospital, Manchester · Great North Children's Hospital, Newcastle upon Tyne

  Registry updated 2026-10-09

• NCT04307576

  A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

  Trial Treatment · Phase 3 · Mats Heyman

  Royal Aberdeen Children's Hospital, Aberdeen, Aberdeen · Aberdeen Royal Infirmary, Aberdeen, Aberdeen · Royal Belfast Hospital for Sick Children, Belfast, Belfast · Belfast City Hospital, Belfast, Belfast · The Queen Elizabeth Hospital, Birmingham, Birmingham · Birmingham Children's Hospital, Birmingham, Birmingham · Bristol Royal Hospital for Children / Bristol Haematology and Oncology Centre, Bristol · Addenbrooke's Hospital Cambridge, Cambridge · Noah's Ark Children's Hospital for Wales, Cardiff, Cardiff · University Hospital of Wales, Cardiff, Cardiff · Royal Hospital for Children and Young People, Edinburgh, Edinburgh · Western General Hospital Edinburgh, Edinburgh · Royal Hospital for Children Glasgow, Glasgow · Beatson West of Scotland Cancer Centre Glasgow, Glasgow · Leeds General Infirmary, Leeds, Leeds · Leeds St James University Hospital, Leeds · Leicester Royal Infirmary, Leicester, Leicester · The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool · Alder Hey Children's Hospital, Liverpool, Liverpool · University College London Hospital, London, London · King's College Hospital, London · Great Ormond Street Hospital for Children, London, London · St Bartholomews Hospital, London · The Christie NHS Foundation Trust (PTC), Manchester · Royal Manchester Children's Hospital, Manchester, Manchester · Freeman Hospital, Newcastle, Newcastle · Royal Victoria Infirmary, Newcastle, Newcastle upon Tyne · Nottingham City Hospital, Nottingham · Nottingham Queen's Medical Centre, Nottingham · Churchill Hospital Oxford, Oxford · John Radcliffe Hospital, Oxford, Oxford · Derriford Hospital, Plymouth · Royal Hallamshire Hospital, Sheffield, Sheffield · Sheffield Children's Hospital, Sheffield, Sheffield · Southampton General Hospital, Southampton, Southampton · Royal Stoke University Hospital, Stoke, Stoke · Royal Marsden Hospital (Sutton), Sutton

  Registry updated 2026-08-12

• NCT05809284

  Determining the Mechanisms of Loss of CAR T Cell Persistence

  Research · University College, London

  University College London Hospital, London · Great Ormond Street Hospital, London · Royal Manchester Children's Hospital, Manchester

  Registry updated 2026-08-07

• NCT04877522

  Asciminib Roll-over Study

  Trial Treatment · Phase 4 · Novartis Pharmaceuticals

  London · Oxford

  Registry updated 2026-07-06

• NCT02443831

  CARPALL: Immunotherapy With CD19+CD22 CAR T-cells for CD19+ and CD22+ Acute Lymphoblastic Leukaemia

  Trial Treatment · Phase 1 · University College, London

  University College Hospital, London · Great Ormond Street Hospital, London · Manchester Royal Children's Hospital, Manchester

  Registry updated 2026-05-22

• NCT04888741

  Methods of T Cell Depletion Trial (MoTD)

  Trial Treatment · Phase 2 · University of Birmingham

  Queen Elizabeth Hospital, Birmingham · Bristol Haematology and Oncology Centre, Bristol · Addenbrookes Hospital, Cambridge · University Hospital of Wales, Cardiff · Queen Elizabeth Hospital Glasgow, Glasgow · St Jame's University Hospital, Leeds · King's College Hospital, London · Hammersmith Hospital, London · University College London Hospital, London · The Christie, Manchester · Manchester Royal Infirmary, Manchester · Freeman Hospital, Newcastle upon Tyne · Nottingham City Hospital, Nottingham · Churchill Hospital, Oxford · Derriford Hospital, Plymouth · Royal Hallamshire Hospital, Sheffield · The Royal Marsden Hospital, Sutton

  Registry updated 2026-05-05

• NCT06051409

  A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1)

  Trial Treatment · Phase 3 · Ascentage Pharma Group Inc.

  Birmingham · Glasgow · London

  Registry updated 2026-04-30

• NCT04988555

  A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

  Trial Treatment · Phase 1/2 · Sumitomo Pharma America, Inc.

  University Hospitals of Birmingham Centre for Clinical Hematology, Birmingham · Bristol Hematology & Oncology Centre, Bristol · NHS Lothian Western General, Edinburgh · Sarah Cannon Research Institute, London · University College London Hospitals NHS Foundation Trust, London · King's College Hospital, London · Christie Hospital NHS Foundation Trust, Manchester · Churchill Hospital Oxford, Oxford · University Hospitals of North Midlands NHS Foundation Trust, Stoke-on-Trent · The Royal Marsden NHS Foundation Trust, Sutton

  Registry updated 2026-03-24

• NCT03590171

  International Study for Treatment of High Risk Childhood Relapsed ALL 2010

  Trial Treatment · Phase 2 · Charite University, Berlin, Germany

  Royal Manchester Children's Hospital, Manchester

  Registry updated 2026-03-17

• NCT07300683

  Anti-CCR9 CAR T Cells for T Cell Leukaemia/Lymphoma

  Trial Treatment · Phase 1 · University College, London

  University College London Hospitals, London

  Registry updated 2025-12-24

• NCT05658640

  HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies

  Trial Treatment · Phase 1/2 · Princess Maxima Center for Pediatric Oncology

  Bristol Royal Hospital for Children, Bristol · Great Ormond Street Hospital For Children NHS Trust, London · Royal Manchester Children's Hospital, Manchester · Great North Children's Hospital, Newcastle · Royal Marsden NHS Trust, Sutton

  Registry updated 2025-09-16

• NCT05745714

  HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

  Trial Treatment · Phase 1/2 · Princess Maxima Center for Pediatric Oncology

  Bristol Royal Hospital for Children, Bristol · Great Ormond Street Hospital For Children NHS Trust, London · Great North Children's Hospital, Newcastle · Royal Marsden NHS Trust, Sutton

  Registry updated 2025-09-16

• NCT05751044

  HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

  Trial Treatment · Phase 1/2 · Princess Maxima Center for Pediatric Oncology

  Bristol Royal Hospital for Children, Bristol · Great Ormond Street Hospital For Children NHS Trust, London · Great North Children's Hospital, Newcastle · Royal Marsden NHS Trust, Sutton

  Registry updated 2025-09-16

• NCT06355583

  Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

  Trial Treatment · Phase 2 · Imperial College London

  University Hospitals Birmingham NHS Foundation Trust, Birmingham · Leeds Teaching Hospital NHS Trust, Leeds · University College London Hospitals NHS Trust, London · Royal Mardsen Hostpital, London · Imperial College Healthcare NHS Trust, London · Kings College NHS Foundation Trust, London · Manchester University NHS Trust, Manchester · Manchester University NHS Foundation Trust, Manchester

  Registry updated 2025-04-17

• NCT06846294

  Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether

  Trial Treatment · University of Exeter

  University Hospitals Bristol & Weston NHS Trust, Bristol

  Registry updated 2025-02-26

All Acute lymphoblastic leukaemia trials and the map

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