Acute lymphoblastic leukaemia trials in United States

In United States 232 Also abroad 564

232 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)
Where
Pittsburgh, Seattle, Tampa
Age
1 year to 60 years
People
120
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT03970096
No phaseTaking people
Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia
Where
Cleveland
Age
Up to 30 years
People
20
Run by
Case Comprehensive Cancer Center
See details and how to joinNCT06421155
Phase 1/2Taking people
A Study of Revumenib and Mezigdomide in People With Leukemia
Where
Basking Ridge, Chapel Hill, Commack, Duarte, Harrison, Houston, Middletown, Montvale, New York, Rockville Centre
Age
12 years and over
People
52
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07356154
Phase 1Taking people
Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant
Where
Duarte
Age
2 years and over
People
27
Run by
City of Hope Medical Center
See details and how to joinNCT06575296
Phase 1/2Taking people
Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias
Where
Bethesda
Age
18 years to 120 years
People
132
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06364423
Phase 1Taking people
Recombinant Erwinia Asparaginase and Venetoclax in Combination With Blinatumomab for the Treatment of Relapsed or Refractory CD19 Positive B-cell Acute Lymphoblastic Leukemia
Where
Duarte
Age
12 years to 55 years
People
26
Run by
City of Hope Medical Center
See details and how to joinNCT07133997
Phase 1/2Taking people
Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Acute Lymphoblastic Leukemia
Where
Chicago, Duarte, Franklin, Houston, Iowa City, Jacksonville
Age
12 years and over
People
83 worldwide
Run by
AstraZeneca
See details and how to joinNCT07109219 · EU 2025-522372-93-00
Phase 1Taking people
Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma
Where
Ann Arbor
Age
18 years and over
People
12
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07532525
Phase 2Taking people
Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia
Where
Atlanta
Age
18 years and over
People
20
Run by
Northside Hospital, Inc.
See details and how to joinNCT05519579
Phase 2Taking people
CAR T-cell Therapy in Patients With Renal Dysfunction
Where
Atlanta
Age
18 years and over
People
20
Run by
Northside Hospital, Inc.
See details and how to joinNCT05909059
Phase 2Taking people
Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome
Where
Duarte
Age
2 years to 22 years
People
40
Run by
City of Hope Medical Center
See details and how to joinNCT06128070
Phase 3Taking people
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
Where
Baltimore, Bethesda, Cincinnati, Coral Springs, Denver, Durham, Hackensack, Hershey, Houston, Jacksonville, Lafayette, Milwaukee, Morristown, New York, Orange, Seattle, The Bronx
Age
18 years and over
People
63 worldwide
Run by
CSL Behring
See details and how to joinNCT07648264 · EU 2026-525626-38-00
Phase 2Not yet taking people in United States
CD34+ Transplants for Myeloid Malignancies
Where
Miami
Age
18 years to 70 years
People
50
Run by
Guenther Koehne
See details and how to joinNCT05565105
Phase 1/2Taking people
AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
Where
Atlanta, Birmingham, Chicago, Duarte, Houston, Los Angeles, Milwaukee, New York, Palo Alto, Richmond, Seattle, Tampa
Age
12 years and over
People
255 worldwide
Run by
AstraZeneca
See details and how to joinNCT06137118 · EU 2023-505840-20-00
Phase 2Taking people
Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Where
Chicago, Cleveland, Duarte, Irvine, La Jolla, Los Angeles, New York, Phoenix
Age
18 years to 54 years
People
53
Run by
City of Hope Medical Center
See details and how to joinNCT06918431
Phase 1/2Taking people
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
Where
Atlanta, Aurora, Boston, Chicago, Cincinnati, Columbus, Duarte, Durham, Hackensack, Houston, Iowa City, Los Angeles, New York, Palo Alto, Philadelphia, Portland, Salt Lake City, Sarasota, St Louis, Tampa
Age
30 days and over
People
447 worldwide
Run by
Syndax Pharmaceuticals
See details and how to joinNCT04065399 · EU 2024-513759-34-00
Phase 1Taking people
A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
Where
Aurora, Chicago, Cincinnati, Los Angeles, Palo Alto, Philadelphia, Salt Lake City, San Antonio, Seattle
Age
0 years to 18 years
People
30 worldwide
Run by
Autolus Limited
See details and how to joinNCT06173518 · EU 2023-506307-26-00
No phaseTaking people
Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients
Where
St Louis
Age
Up to 30 years
People
60
Run by
Washington University School of Medicine
See details and how to joinNCT07313592
Phase 2Taking people
Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Where
Houston
People
160
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT00501826
Phase 2Not yet taking people in United States
Phase II Study of the Combination of Subcutaneous Blinatumomab and Olverembatinib in Patients With Philadelphia Chromosome (ph)-Positive and/or BCR::ABL1 Positive Acute Lymphoblastic Leukemia (ALL)
Where
Houston
Age
18 years and over
People
60
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07178912
Early phase 1Taking people
Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Bone Marrow or Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies
Where
Baltimore
Age
18 years and over
People
8
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT06398457
Phase 2Enrolling by invitation
Adding Asciminib to Usual Treatment for Adults With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia
Where
Albuquerque, Bellevue, Cincinnati, Cleveland, Detroit, Durham, Lake Success, Memphis, Omaha, Orange, Pittsburgh, Providence, Rochester, Tucson
Age
60 years and over
People
55
Run by
SWOG Cancer Research Network
See details and how to joinNCT06773936
No phaseNot yet taking people in United States
2 Gy Total Body Irradiation As Part Of Conditioning Treatment For Patients With Acute Lymphoblastic Leukemia Undergoing CAR T Cell Therapy
Where
Houston
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07856758
No phaseEnrolling by invitation
Measurement of Ocular Microtremor With the iTremor Device in a Diverse US Cohort
Where
Atlanta, Cambridge
Age
18 years and over
People
120
Run by
Head Diagnostics
See details and how to joinNCT07858214
Phase 1Taking people
Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)
Where
Houston
Age
Up to 75 years
People
64
Run by
Baylor College of Medicine
See details and how to joinNCT01853631