Chronic lymphocytic leukaemia: open trials in Australia

29 open trials have a site in Australia. Registry data; only the trial team decides who can take part.

NCT05947851
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Royal Adelaide Hospital (Site 1104), Adelaide · Box Hill Hospital (Site 1106), Box Hill · Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research (Site 1103), Melbourne
Registry updated 2026-11-06
NCT05091424
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
Trial Treatment · Phase 1 · Hoffmann-La Roche
Peter MacCallum Cancer Center, East Melbourne · Monash Medical Centre, Melbourne · Princess Alexandra Hospital Woolloongabba, Woolloongabba
Registry updated 2026-11-05
NCT06588478
A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 2 · Loxo Oncology, Inc.
Flinders Medical Centre, Adelaide · Bankstown-Lidcombe Hospital, Bankstown · Box Hill Hospital, Box Hill · Coffs Harbour Health Campus, Coffs Harbour · Royal Hobart Hospital, Hobart · Icon Cancer Centre Kurralta Park, Kurralta Park · Latrobe Regional Health, Traralgon · Calvary Mater Newcastle, Waratah · The Perth Blood Institute - West Perth, West Perth · Princess Alexandra Hospital, Woolloongabba
Registry updated 2026-11-04
NCT06788509
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
Trial Treatment · Phase 1 · Janssen Research & Development, LLC
Macquarie University Hospital, Macquarie University · The Alfred Hospital, Melbourne · Linear Clinical Research Ltd, Nedlands · Scientia Clinical Research, Randwick
Registry updated 2026-11-04
NCT07218341
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 4 · Eli Lilly and Company
The Alfred Hospital, Melbourne
Registry updated 2026-11-04
NCT06564038
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Trial Treatment · Phase 1/2 · AstraZeneca
Heidelberg · Melbourne · Nedlands
Registry updated 2026-10-28
NCT04728893
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Box Hill Hospital (Site 0203), Box Hill · Sir Charles Gairdner Hospital (Site 0200), Nedlands · Nepean Hospital-Nepean Cancer Care Centre (Site 0204), Sydney
Registry updated 2026-10-27
NCT06697184
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Trial Treatment · Phase 1/2 · BeOne Medicines
GenesisCare - St Andrews, Adelaide · Blacktown Cancer and Haematology Centre, Blacktown · Rockingham Hospital, Cooloongup · Cabrini Hospital - Malvern, Malvern · The Alfred Hospital, Melbourne · Linear Clinical Research, Nedlands
Registry updated 2026-10-26
NCT06943872
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Trial Treatment · Phase 3 · BeOne Medicines
Sunshine Coast Hospital and Health Service, Birtinya · Blacktown Cancer and Haematology Centre, Blacktown · Monash Health, Clayton · Rockingham Hospital, Cooloongup · St Vincents Hospital Melbourne, Fitzroy · St George Hospital, Kogarah · Northern Nsw Health District, Lismore · Peter MacCallum Cancer Centre, Melbourne · The Alfred Hospital, Melbourne · Macquarie University, North Ryde · GenesisCare - North Shore, St Leonards · Perth Blood Institute, West Perth · Princess Alexandra Hospital, Woolloongabba
Registry updated 2026-10-23
NCT06528301
A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies
Trial Treatment · Phase 1 · Umoja Biopharma
St Vincent's Hospital Melbourne, Fitzroy · Royal North Shore Hospital, Saint Leonards
Registry updated 2026-10-15
NCT06136559
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Royal North Shore Hospital (Site 2806), St Leonards
Registry updated 2026-10-13
NCT07509151
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
Trial Treatment · Phase 3 · AstraZeneca
Adelaide · Fitzroy · Heidelberg · Nedlands · Perth · Rockingham
Registry updated 2026-10-06
NCT05006716
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Trial Treatment · Phase 1/2 · BeOne Medicines
Concord Repatriation General Hospital, Concord · St Vincents Hospital Melbourne, Fitzroy · Austin Health, Heidelberg · Peter MacCallum Cancer Centre, Melbourne · The Alfred Hospital, Melbourne · Linear Clinical Research, Nedlands · Calvary Mater Newcastle, Waratah · Perth Blood Institute, West Perth · Princess Alexandra Hospital, Woolloongabba
Registry updated 2026-10-05
NCT05791409
Venetoclax Treatment (26 Cycles) With 6 Cycles or 12 Cycles of Epcoritamab in Patients With Relapsed or Refractory CLL or SLL
Trial Treatment · Phase 1/2 · Stichting Hemato-Oncologie voor Volwassenen Nederland
AU-Melbourne-SVHM, Melbourne · AU-Melbourne-MONASH, Melbourne · AU-Melbourne-ALFRED, Melbourne
Registry updated 2026-10-05
NCT06542250
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Trial Treatment · Phase 1/2 · AstraZeneca
Melbourne · Nedlands
Registry updated 2026-09-30
NCT06846671
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
Trial Treatment · Phase 3 · BeOne Medicines
Flinders Medical Centre, Bedford PK · Concord Repatriation General Hospital, Concord · Gosford Hospital, Gosford · The Alfred Hospital, Melbourne · Port Macquarie Base Hospital, Port Macquarie · Prince of Wales Hospital, Randwick · Toowoomba Hospital, Toowoomba · Perth Blood Institute, West Perth
Registry updated 2026-09-28
NCT06973187
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Trial Treatment · Phase 3 · BeOne Medicines
Flinders Medical Centre, Bedford PK · Pindara Private Hospital, Benowa · Sunshine Coast Hospital and Health Service, Birtinya · Concord Repatriation General Hospital, Concord · St Vincents Hospital Melbourne, Fitzroy · Peninsula Private Hospital, Frankston · Austin Health, Heidelberg · St George Private Hospital, Kogarah · Cabrini Hospital - Malvern, Malvern · The Alfred Hospital, Melbourne · Peter MacCallum Cancer Centre, Melbourne · Linear Clinical Research, Nedlands · John Flynn Private Hospital, Tugun · Westmead Private Hospital, Westmead
Registry updated 2026-09-28
NCT07277231
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Trial Treatment · Phase 3 · BeOne Medicines
Blacktown Cancer and Haematology Centre, Blacktown · Monash Health, Clayton · Concord Repatriation General Hospital, Concord · Austin Health, Heidelberg · Cabrini Hospital - Malvern, Malvern · The Alfred Hospital, Melbourne · GenesisCare - North Shore, St Leonards · Princess Alexandra Hospital, Woolloongabba
Registry updated 2026-09-28
NCT03666000
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
Trial Treatment · Phase 1 · Imugene Limited
Royal Adelaide Hospital, Adelaide · Royal Prince Alfred Hospital, Camperdown · St Vincent's Hospital Melbourne, Fitzroy · Barwon Health - Andrew Love Cancer Centre, Geelong · Liverpool Hospital, Liverpool
Registry updated 2026-09-08
NCT06812715
Clonal Dynamics of Chronic Lymphocytic Leukaemia Treated With Pirtobrutinib After Previous Treatment With Zanubrutinib
Trial Treatment · Phase 2 · Peter MacCallum Cancer Centre, Australia
Peter MacCallum Cancer Centre, Melbourne · Monash Medical Centre, Melbourne · Alfred Hospital, Melbourne
Registry updated 2026-09-03
NCT05254743
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Trial Treatment · Phase 3 · Loxo Oncology, Inc.
One Clinical Research, Nedlands · Western Health Sunshine Hospital, St Albans · The Perth Blood Institute, West Perth
Registry updated 2026-08-17
NCT06104566
Global Trial in APG2575 for Patients With CLL/SLL
Trial Treatment · Phase 3 · Ascentage Pharma Group Inc.
Gosford · Perth · Westmead
Registry updated 2026-06-18
NCT06428019
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Trial Treatment · Phase 3 · AbbVie
St Vincent's Hospital - Melbourne /ID# 270027, Fitzroy · Royal Perth Hospital /ID# 266906, Perth · Townsville University Hospital /ID# 266954, Townsville · Calvary Mater Newcastle /ID# 267408, Waratah
Registry updated 2026-04-09
NCT06876649
A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib
Trial Treatment · Phase 4 · Eli Lilly and Company
Flinders Medical Centre, Adelaide · Peter MacCallum Cancer Centre, Melbourne · Linear Clinical Research, Victoria
Registry updated 2026-03-02
NCT06876662
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Trial Treatment · Phase 4 · Eli Lilly and Company
Flinders Medical Centre, Adelaide · Peter MacCallum Cancer Centre, Melbourne · Linear Clinical Research, Victoria
Registry updated 2026-03-02

All Chronic lymphocytic leukaemia trials and the map

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