Chronic lymphocytic leukaemia: open trials in Spain

42 open trials have a site in Spain. Registry data; only the trial team decides who can take part.

2026-525234-39-00
A Phase 1 Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies
Trial Treatment · Phase 1 · Janssen Cilag International
Hospital Clinic de Barcelona, Barcelona · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Clínica Universidad de navarra, Pamplona
Registry updated 2026-11-06
NCT05947851
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department (Site 4601), L'Hospitalet Del Llobregat · HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID (Site 4602), Pozuelo de Alarcón · HOSPITAL CLINICO DE VALENCIA-HEMATOLOGY (Site 4603), Valencia
Registry updated 2026-11-06
NCT05091424
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia
Trial Treatment · Phase 1 · Hoffmann-La Roche
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona
Registry updated 2026-11-05
NCT05999877
PICAROS - Acalabrutinib RWE on 1L CLL in Spain
Research · AstraZeneca
Alicante · Almería · Barcelona · Córdoba · Donostia / San Sebastian · El Palmar · Galdakao · Granada · Granollers · Guadalajara · Jaén · Las Palmas de Gran Canaria · L'Hospitalet de Llobregat · Lleida · Madrid · Majadahonda · Málaga · Marbella · Murcia · Ourense · Oviedo · Palma de Mallorca · Salamanca · San Cristóbal de La Laguna · Santander · Santiago de Compostela · Segovia · Seville · Terrassa · Toledo · Valencia · Valladolid · Vigo · Zaragoza
Registry updated 2026-11-04
NCT06588478
A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 2 · Loxo Oncology, Inc.
Hospital Universitari Vall d'Hebron, Barcelona · Hospital Clinic de Barcelona, Barcelona · Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat · Hospital Universitario Ramón y Cajal, Madrid · MD Anderson Cancer Center, Madrid · Hospital Universitario Infanta Leonor, Madrid · Clinica Universidad de Navarra, Madrid · Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda · Hospital Costa del Sol, Marbella · Hospital Universitario Central De Asturias, Oviedo · Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca · Hospital Universitario Marqués de Valdecilla, Santander · Hospital Universitario Virgen del Rocio, Seville · Hospital Universitario Virgen Macarena, Seville
Registry updated 2026-11-04
NCT06788509
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
Trial Treatment · Phase 1 · Janssen Research & Development, LLC
Hospital Universitari Vall d'Hebron, Barcelona · Hospital Clinic de Barcelona, Barcelona · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Clínica Universidad de navarra, Pamplona · Hospital Universitario De Salamanca, Salamanca
Registry updated 2026-11-04
NCT07218341
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Trial Treatment · Phase 4 · Eli Lilly and Company
Hospital Universitario Marqués de Valdecilla, Santander · Hospital Universitario Virgen del Rocio, Seville
Registry updated 2026-11-04
2023-510147-37-00
Acalabrutinib Monotherapy vs Investigator’s Choice of Treatment in Patients with Chronic Lymphocytic Leukaemia and Moderate to Severe Cardiac Impairment
Trial Treatment · Phase 4 · AstraZeneca AB
Hospital del Mar, Barcelona · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Virgen De La Macarena, Sevilla
Registry updated 2026-10-28
NCT06564038
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Trial Treatment · Phase 1/2 · AstraZeneca
Hospital Clinic de Barcelona, Barcelona · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · University Hospital Son Espases, Palma · Complexo Hospitalario Universitario De Santiago, Santiago de Compostela · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-10-28
NCT04728893
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
CHUAC-Complejo Hospitalario Universitario A Coruña (Site 2005), A Coruña · Hospital General Universitario de Alicante (Site 2007), Alicante · Hospital Universitari Vall d'Hebron (Site 2001), Barcelona · Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals (Site 2000), L'Hospitalet de Llobregat · Hospital Universitario 12 de Octubre (Site 2003), Madrid · Hospital Puerta de Hierro (Site 2009), Madrid · Hospital Universitario de Salamanca (Site 2002), Salamanca
Registry updated 2026-10-27
NCT06697184
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Trial Treatment · Phase 1/2 · BeOne Medicines
Institut Catala D'oncologia, L'Hospitalet de Llobregat · Hospital General Universitario Gregorio Marañón, Madrid · Complejo Asistencial Universitario de Salamanca, Salamanca
Registry updated 2026-10-26
NCT06943872
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Trial Treatment · Phase 3 · BeOne Medicines
Hospital Clinic de Barcelona, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Institut Catala D'oncologia, L'Hospitalet de Llobregat · Hospital Universitario Infanta Leonor, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Costa del Sol, Marbella · Hospital Universitario De Salamanca, Salamanca · Hospital Universitario Marqués de Valdecilla, Santander · Hospital Universitario Virgen De Valme, Sevilla
Registry updated 2026-10-23
NCT07024706
MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab
Trial Treatment · Phase 2 · AstraZeneca
Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Virgen de las Nieves, Granada · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Infanta Leonor, Madrid · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda
Registry updated 2026-10-23
NCT07648264
Single-arm Study of IgPro20 in Adults With Secondary Immune Deficiencies Due to Hematologic Malignancies Treated With B-cell Targeting Chimeric Antigen Receptor T-cell and T-cell Redirecting Therapies
Trial Treatment · Phase 3 · CSL Behring
Hospital Universitari Germans Trias i Pujol, Badalona · Vall d'Hebron Institut d'Oncologia, Barcelona · Hospital Clinic de Barcelona, Barcelona · Hospital Universitario del Vinalopo, Elche · Pratia ES HLA Hospital Universitario Moncloa, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Marqués de Valdecilla, Santander
Registry updated 2026-10-14
NCT06136559
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Hospital Clinic de Barcelona, Barcelona · Vall D'hebron Institut De Recerca, Barcelona · Institut Catala D'oncologia, L'Hospitalet de Llobregat · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Universitario De Salamanca, Salamanca · University Hospital Of Canary Islands, San Cristobal De La Laguna
Registry updated 2026-10-13
NCT03934372
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
Trial Treatment · Phase 1/2 · Incyte Biosciences International Sàrl
Hospital General Universitario Vall D Hebron, Barcelona · Hospital Sant Joan de Deu de Manresa, Barcelona · Hospital Infantil Unversitario Nino Jesus, Madrid · Hospital Universitari i Politécnic La Fe, Valencia
Registry updated 2026-10-09
NCT05006716
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Trial Treatment · Phase 1/2 · BeOne Medicines
Hospital Universitario Vall Dhebron, Barcelona · Hospital Universitario La Paz, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Md Anderson Cancer Center Madrid Spain, Madrid · Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda · Hospital Clinico Universitario de Valencia, Valencia
Registry updated 2026-10-05
2023-510294-34-00
A phase 3 multicenter, randomised, prospective, open-label trial of fixed-duration (12 cycles) venetoclax/ obinutuzumab vs. fixed-duration (15 cycles) venetoclax/ pirtobrutinib vs. MRD-guided venetoclax/ pirtobrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL) aiming to establish measurement of individual residual disease for adjustment of treatment duration to improve outcomes (CLL18/ MOIRAI)
Trial Treatment · Phase 3 · University Of Cologne
Hospital General Universitario Dr. Balmis, Alicante · Institut Catala d'Oncologia, Badalona · Hospital Clinic de Barcelona, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital del Mar, Barcelona · Hospital Universitario Reina Sofia, Córdoba · Hospital Universitario Donostia, Donostia · El Hospital Universitario De Gran Canaria Dr. Negrin, Las Palmas De Gran Canaria · Institut Catala D'oncologia, L'Hospitalet de Llobregat · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario La Paz, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Infanta Leonor, Madrid · Hospital Universitario Regional de Málaga, Málaga · Hospital Costa del Sol, Marbella · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario Central De Asturias, Oviedo · Hospital Universitario De Salamanca, Salamanca · Hospital Universitario Marqués de Valdecilla, Santander · Complexo Hospitalario Universitario De Santiago, Santiago de Compostela · Hospital Universitario Virgen De Valme, Sevilla · Hospital Clinico Universitario de Valencia, Valencia · Hospital Clinico Universitario Lozano Blesa, Zaragoza
Registry updated 2026-10-01
NCT07582432
A Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex in Participants With Secondary Antibody Deficiency Associated With Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma
Trial Treatment · Phase 3 · Grifols Biologicals, LLC
Institut catlá d'oncologia-Badalona, Badalona · Hospital San Pedro De Alcántara, Cáceres · Hospital Universitario Infanta Leonor, Madrid · Hospital Universitario de Navarra, Pamplona · Hospital Universitario Y Politecnico La Fe, Valencia · Clinica Universidad De Navarra · Hospital Universitario Quironsalud Madrid
Registry updated 2026-10-01
NCT06542250
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Trial Treatment · Phase 1/2 · AstraZeneca
Barcelona · L'Hospitalet de Llobregat · Madrid
Registry updated 2026-09-30
NCT06973187
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Trial Treatment · Phase 3 · BeOne Medicines
Institut Catala d'Oncologia, Badalona · Hospital Universitario De Burgos, Burgos · El Hospital Universitario De Gran Canaria Dr. Negrin, Las Palmas De Gran Canaria · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · University Hospital Son Espases, Palma · University Hospital Virgen Del Rocio S.L., Sevilla
Registry updated 2026-09-28
NCT07277231
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Trial Treatment · Phase 3 · BeOne Medicines
Hospital Universitario Virgen de las Nieves, Granada · Hospital Universitario 12 de Octubre, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · University Clinical Hospital Virgen De La Arrixaca, Murcia
Registry updated 2026-09-28
NCT06651970
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Trial Treatment · Phase 4 · AstraZeneca
Barcelona · Madrid · Seville
Registry updated 2026-09-24
2023-510173-34-00
A long-term follow-up study for patients treated with Galapagos CAR T cell therapies
Trial Treatment · Phase 3 · Lakefront Biotherapeutics
Hospital Clinic de Barcelona, Barcelona
Registry updated 2026-09-11
NCT05254743
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Trial Treatment · Phase 3 · Loxo Oncology, Inc.
Hospital Universitari Vall d'Hebron, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Hospital Clinic de Barcelona, Barcelona · Institut Català d'Oncologia, Girona · Clinica Universidad de Navarra, Madrid · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario Infanta Leonor, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · Hospital Costa del Sol, Marbella · Hospital Universitario de Navarra, Pamplona · Hospital Universitario Marqués de Valdecilla, Santander · University Hospital Virgen Del Rocio S.L., Sevilla · Hospital Universitario Virgen De La Macarena, Sevilla
Registry updated 2026-08-17

All Chronic lymphocytic leukaemia trials and the map

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