Chronic lymphocytic leukaemia trials in France

In France 49 Also abroad 308

49 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantation
Where
Amiens, Angers, Besançon, Clermont-Ferrand, Grenoble, Lille, Limoges, Lyon, Nancy, Nantes, Nice, Paris, Pessac, Poitiers, Rouen, Saint-Etienne, Toulouse
Age
18 years and over
People
150
Run by
University Hospital, Clermont-Ferrand
See details and how to joinNCT04935684
Phase 2Not yet taking people in France
Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Where
Argenteuil Cedex, Avignon, Bayonne, Bordeaux, Clermont-Ferrand, Corbeil-Essonnes, Grenoble Cedex 9, Le Chesnay Cedex, Le Mans Cedex 9, Lille Cedex, Lyon, Orleans Cedex 2, Pierre-Bénite, Pontoise, Rouen Cedex, Toulouse Cedex 9, Vandoeuvre Les Nancy Cedex
Age
80 years and over
People
95
Run by
The Lymphoma Academic Research Organisation
See details and how to joinNCT07739459 · EU 2025-525080-32-00
Phase 2Taking people
A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor (BTKi) and a Bcell Lymphoma-2 Inhibitor (BCL-2i) (DAYBreak CLL-201)
Where
Nantes
Age
18 years and over
People
45 worldwide
Run by
Nurix Therapeutics Inc.
See details and how to join2025-521088-10-00
Phase 2Taking people
FILOCLL015 - GLORIFY - A phase 2 study evaluating the bispecific CD3xCD20 antibody GLOfitamab in combination with rituximab or obinutuzumab plus cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) in patients with RIchter syndrome as Frontline therapY
Where
Amiens, Angers Cedex 9, Bayonne, Clermont-Ferrand, Dijon, Grenoble Cedex 9, Le Chesnay Rocquencourt, Le Mans Cedex 9, Lille Cedex, Limoges, Lomme Cedex, Lyon, Montpellier Cedex 5, Mulhouse, Orleans Cedex 2, Paris, Paris Cedex 12, Pessac, Pierre Benite Cedex, Reims Cedex, Rennes Cedex 9, Rouen, Saint-Priest-en-Jarez, Strasbourg Cedex 2, Toulouse, Tours Cedex 9, Vandoeuvre Les Nancy
Age
18 years and over
People
40
Run by
French Innovative Leukemia Organization
See details and how to join2022-501554-11-00
Phase 3Taking people
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Where
La Roche Sur Yon Cedex 9, Le Mans Cedex 9, Limoges, Nantes, Nice Cedex 2, Paris Cedex 13, Pierre-Bénite, Rennes, Rouen Cedex, Tours
Age
18 years and over
People
737 worldwide
Run by
Loxo Oncology, Inc.
See details and how to joinNCT05254743 · EU 2023-507699-38-00
Phase 1Taking people
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
Where
Bordeaux, Marseille, Nantes
Age
18 years and over
People
85 worldwide
Run by
Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
See details and how to joinNCT06980116 · EU 2024-516869-36-00
Phase 1Taking people
Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia
Where
Clermont-Ferrand, Toulouse
Age
18 years and over
People
54 worldwide
Run by
F. Hoffmann-La Roche AG
See details and how to join2022-501876-24-00
Phase 2Not yet taking people in France
Epcoritamab Plus Venetoclax Plus Ibrutinib in Patients With Chronic Lymphocytic Leukemia With TP53 Alterations
Where
Angers, Caen Cedex 9, Chambéry, Clermont-Ferrand, La Roche Sur Yon Cedex 9, Le Mans Cedex 9, Lille Cedex, Marseille, Metz Cedex 03, Mont-De-Marsan Cedex, Montpellier Cedex 5, Nantes, Nice Cedex 2, Paris, Pessac, Pierre-Bénite, Poitiers, Pontoise, Rennes Cedex 9, Saint-Priest-en-Jarez, Strasbourg Cedex, Toulouse Cedex 9, Villejuif Cedex
Age
18 years to 79 years
People
44 worldwide
Run by
The Lymphoma Academic Research Organisation
See details and how to joinNCT07738887 · EU 2025-520893-20-00
Phase 1Taking people
A Study to Test How Safe, Effective and How the Body Responds to the Combination of Mosunetuzumab and Pirtobrutinib Together to Treat Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Where
Clermont-Ferrand, Toulouse
Age
18 years and over
People
22 worldwide
Run by
F. Hoffmann-La Roche AG
See details and how to join2024-514152-32-00
No phaseTaking people
Determinants of the Response to BTK Degraders (BTKd) in Chronic Lymphocytic Leukemia
Where
Angers, Bordeaux, Clermont-Ferrand, La Roche-sur-Yon, Lyon, Marseille, Montpellier, Nancy, Nantes, Paris, Poitiers, Rouen
Age
18 years and over
People
60
Run by
Nantes University Hospital
See details and how to joinNCT07099443
Phase 1Taking people
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Where
Angers, Bobigny, Nantes, Pessac, Poitiers, Saint-Cloud, Vandœuvre-lès-Nancy
Age
18 years and over
People
572 worldwide
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT05131022 · EU 2023-510541-25-00
Phase 3Taking people
Global Trial in APG2575 for Patients With CLL/SLL
Where
Clermont-Ferrand, Le Mans Cedex 9, Lyon, Nantes, Nantes Cedex 2, Nice Cedex 2, Nimes Cedex 9, Orleans Cedex 2, Poitiers, Pontoise, Strasbourg, Tours Cedex 9
Age
18 years to 99 years
People
400 worldwide
Run by
Ascentage Pharma Group Inc.
See details and how to joinNCT06104566 · EU 2023-508005-24-00
No phaseTaking people
Evaluation of Skin Tests in Biotherapy Allergies
Where
Angers
Age
18 years and over
People
70
Run by
University Hospital, Angers
See details and how to joinNCT06971848
Phase 2Not yet taking people in France
Fixed Duration Treatment With Combined Pirtobrutinib and Short Course Immuno-chemotherapy in Fit Patients With Previously Untreated Symptomatic Chronic Lymphocytic Leukemia (CLL).
Where
Amiens Cedex 1, Angers, Argenteuil Cedex, Avignon, Bayonne, Besançon, Chambéry, Clermont-Ferrand, Corbeil-Essonnes, Epagny Metz-tessy, Grenoble, Grenoble Cedex 9, La Roche-sur-Yon, Le Mans Cedex 9, Lyon, Mont-De-Marsan Cedex, Mulhouse, Nantes, Nantes Cedex 2, Nice Cedex 2, ORLEANS, Paris, Poitiers, Reims Cedex, Rouen, Saint-Priest-en-Jarez, Strasbourg Cedex, Tours Cedex 9, Valence, Vandoeuvre Les Nancy
Age
18 years and over
People
82
Run by
French Innovative Leukemia Organisation
See details and how to joinNCT07624799 · EU 2025-521199-80-00
Phase 3Taking people
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Where
Amiens Cedex 1, Argenteuil Cedex, Bayonne, Chambéry, Creteil, Metz Cedex 03, Nice Cedex 2, Orleans Cedex 2, Paris, Saint-Priest-en-Jarez
Age
18 years and over
People
170 worldwide
Run by
AbbVie
See details and how to joinNCT06428019 · EU 2024-512147-23-00
Phase 4Taking people
ETCABio - Evaluation of Skin Tests in Biotherapy Allergies
Where
Angers
Age
18 years and over
People
140
Run by
Centre Hospitalier Universitaire D'Angers
See details and how to join2024-519812-15-00
Phase 4Taking people
A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib
Where
Nantes
Age
18 years and over
People
787 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06876649
Phase 4Taking people
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Where
Nantes
Age
18 years and over
People
279 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06876662
Phase 1Taking people
Study of SGR-1505 in Mature B-Cell Neoplasms
Where
Creteil Cedex, Villejuif
Age
18 years and over
People
98 worldwide
Run by
Schrödinger, Inc.
See details and how to joinNCT05544019 · EU 2023-505204-34-00
Phase 3Not yet taking people in France
A Multicenter Trial Evaluating Efficacy and Safety of A Reduced Venetoclax Exposure To Seven Days Versus Standard Continuous Venetoclax Exposure Combined With Azacitidine in Treatment Naïve Subjects With Acute Myeloid Leukemia Who Are Ineligible for Intensive Induction
Where
Amiens Cedex 1, Bayonne, Bobigny, Le Chesnay Rocquencourt, Mulhouse, Paris, Perpignan Cedex, Toulouse, Vandoeuvre Les Nancy Cedex, Villejuif
Age
70 years and over
People
262 worldwide
Run by
Gustave Roussy, Cancer Campus, Grand Paris
See details and how to joinNCT07082452 · EU 2025-521634-29-00
No phaseTaking people
Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
Where
Reims
Age
18 years and over
People
75
Run by
CHU de Reims
See details and how to joinNCT06475469
No phaseTaking people
Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia
Where
Amiens, Besançon, Bobigny, Clermont-Ferrand, Grenoble, Lille, Lyon, Montpellier, Nancy, Paris, Pessac, Reims, Toulouse
Age
18 years and over
People
50
Run by
University Hospital, Clermont-Ferrand
See details and how to joinNCT05246345
Phase 1/2Taking people
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
Where
Nantes, Rouen, Tours
Age
18 years and over
People
84 worldwide
Run by
Kartos Therapeutics, Inc.
See details and how to joinNCT04502394
No phaseTaking people
Institut Paoli Calmettes Chronic Lymphatic Leukemia Database
Where
Marseille
Age
18 years to 95 years
People
4,200
Run by
Institut Paoli-Calmettes
See details and how to joinNCT02869529