Chronic lymphocytic leukaemia: open trials in Ireland

• NCT07218341

  A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  Trial Treatment · Phase 4 · Eli Lilly and Company

  St. James's Hospital, Dublin · Beaumont Hospital, Dublin

  Registry updated 2026-11-04

• NCT04728893

  Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

  Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC

  Beaumont Hospital (Site 2900), Dublin · University Hospital Limerick (Site 2903), Limerick

  Registry updated 2026-10-27

• NCT06943872

  A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

  Trial Treatment · Phase 3 · BeOne Medicines

  Mater Misericordiae University Hospital, Dublin 7 · St James's Hospital, Dublin 8 · University Hospital Galway, Galway · University Hospital Limerick, Limerick

  Registry updated 2026-10-23

• NCT07024706

  MAVRiC Studies 2L Treatment With AV in Patients With CLL/SLL Who Have Relapsed After a Course of BTKi + BCL2i Combination, With or Without Obinutuzumab

  Trial Treatment · Phase 2 · AstraZeneca

  Mater Misericordiae University Hospital, Dublin 7 · St James's Hospital, Dublin 8

  Registry updated 2026-10-23

• 2023-510294-34-00

  A phase 3 multicenter, randomised, prospective, open-label trial of fixed-duration (12 cycles) venetoclax/ obinutuzumab vs. fixed-duration (15 cycles) venetoclax/ pirtobrutinib vs. MRD-guided venetoclax/ pirtobrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL) aiming to establish measurement of individual residual disease for adjustment of treatment duration to improve outcomes (CLL18/ MOIRAI)

  Trial Treatment · Phase 3 · University Of Cologne

  Cork University Hospital, Cork · Mater Misericordiae University Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · University Hospital Galway, Galway · University Hospital Limerick, Limerick · University Hospital Waterford, Waterford

  Registry updated 2026-10-01

All Chronic lymphocytic leukaemia trials and the map

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